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进展型多发性硬化症的治疗：什么可行什么不可行并且我们需要的是什么
作者：陈亚云 编译
来源：医学论坛网
此文章来源于
Treatment of progressive multiple sclerosis: what works, what does not, and what is needed
Prof&,&MD,&,&,&,&PhD,&,&MD
Disease-modifying drugs have mostly failed as treatments for progressive multiple sclerosis. Management of the disease therefore solely aims to minimise symptoms and, if possible, improve function. The degree to which this approach is based on empirical data derived from studies of progressive disease or whether treatment decisions are based on what is known about relapsing-remitting disease remains unclear. Symptoms rated as important by patients with multiple sclerosis include balance and mobility impairments, weakness, reduced cardiovascular fitness, ataxia, fatigue, bladder dysfunction, spasticity, pain, cognitive deficits, depression, and a comprehensive literature search shows a notable paucity of studies devoted solely to these symptoms in progressive multiple sclerosis, which translates to few proven therapeutic options in the clinic. A new strategy that can be used in future rehabilitation trials is therefore needed, with the adoption of approaches that look beyond single interventions to concurrent, potentially synergistic, treatments that maximise what remains of neural plasticity in patients with progressive multiple sclerosis.
This is the second in a&Series&of three papers about progressive multiple sclerosis
Introduction
More than 20 years have passed since the introduction of the first disease-modifying treatment for multiple sclerosis, interferon beta-1b.&Since then, nine further treatments have been approved and entered the market. All these drugs are for relapsing-remitting multiple sclerosis (RRMS), apart from interferon beta-1b (Betaseron), which has also been approved for use in secondary progressive multiple sclerosis (SPMS), but does not delay disability progression.&Therefore, the half of patients with multiple sclerosis who have progressive disease have been left behind by the therapeutic bandwagon. This situation raises the question of how we can help patients with primary progressive multiple sclerosis (PPMS) and SPMS. Although research is ongoing to find a treatment that could halt further deterioration in a disease that has already entered a progressive stage, in the meantime patients and their clinicians only have symptomatic treatment options. As we will make clear in this Series paper, many treatments and strategies are available for a disease with such diverse symptoms. However, the degree to which existing therapeutic approaches are based on empirical data derived from clinical trials confined to patients with progressive disease remains unclear. A critical review of the evidence is therefore timely. In the absence of disease-modifying treatments, what works symptomatically and what does not take on an even greater salience.
To choose which symptoms to include in this Series paper, we noted the views of patients with multiple sclerosis who have rated their symptoms in their perceived order of importance.&We have also linked these symptoms to quality-of-life indices&and have added our opinions regarding symptom significance, based on our clinical experience. The result is a Series paper that encompasses treatments for the following multiple sclerosis-related health issues: balance and mobility impairment, weakness, reduced cardiovascular fitness, ataxia, fatigue, bladder dysfunction, spasticity, pain, cognitive deficits, depression, and pseudobulbar affect.
The Lancet Neurology
, February 2015, Pages 194&207
进展型多发性硬化症,治疗
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职称:医院:中日友好医院科室:
职称:医院:卫生部中日友好医院科室:
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邮&&&&箱：多发性硬化病，MS，能彻底治疗好吗，在那里治疗，有彻底治疗好的吗，有知道到的，告诉我一下谢谢了，或偏方也好啊，谢谢大家、
多发性硬化病，MS，能彻底治疗好吗，在那里治疗，有彻底治疗好的吗，有知道到的，告诉我一下谢谢了，或偏方也好啊，谢谢大家、
不区分大小写匿名
不知道，╮(╯▽╰)╭
不好意思啊，不知道。
应该在骨科医院治疗，也要看病人的情况
早中期治疗都可以恢复。多发性硬化是脱髓鞘病灶因治疗缺迟发复发导致病灶缺血变性纤维化，可以治愈，但非激素能愈，激素并不治病，是激发人体最佳抗病替能的药物，经它治疗淹盖病情，病毒替伏，大量的激素使用会导致免疫更为低下，加之本身的神经功能不全偶遇病毒或炎症病情就会复发再度的严重损伤脊髓，若失治或延误治疗则会继发更严重的多发性硬化灶，反复的复发病毒会侵袭整个脑部和脊髓导致瘫痪并危机生命.早期的治疗多以激素及蛋白疗法治疗，但疗效难以控固，由于长期的治疗缺乏致病情有时继发轴索损害,从而复发使神经功能症状进一步加重.病情继发加重后恢复更为困难。治疗方案：治疗除正常的激素治疗在减激素的同时可逐步用中药替代天然激素且对人体无毒副作用.应增强机体免疫功能，提高肌体抗病能力。营养神经，中西医复合扩张微循环使受损残余神经得到充分的血供，预防病情继续发展。并兴奋激活麻痹休克的神经才能再生修复病灶恢复神经，并使体内产生病毒抗体不再复发达获得各种功能早日康复，。需帮助发来发病时和最近的磁共震照片，病历，病史为你指导。
相关知识等待您来回答
医院领域专家好心人救命我是_名多发性硬化告诉那里治_百度知道
好心人救命我是_名多发性硬化告诉那里治
我有更好的答案
按默认排序
甲等医院应该都能看 说治愈 目前没吧 说能治都忽悠吧 能治 赚钱啊 都能拿诺贝尔医奖
放态 能事 能事
复发 非 激素 干扰素 免疫球蛋白 营养神经药
你好，我也是和你一样，现在复发三次了。激素一次比一次多。你现在严重吗？
到上海的华山医院，我的一个朋友几年前也是同样的疾病到那里看过
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