HMRW治疗失眠多梦的特效药?12 失眠多...

你是女的吧?你性格看起来比较内向 不要太在意某件事 人活着就要开心快乐 心烦意燥的时候试着分散注意力 把事情往好的方面想 其实哭也不是什么坏事 不影响你生活就行了 人各有自己的发泄方式 哭也是一种~
其他答案(共7个回答)
病情分析:
你这属于长期的压力导致的,情绪失控
指导意见:
建议你要调理自己的心情,学会放松,有压力要及时的倾诉,不要压在心里,多交朋友,多和朋友一块娱乐,保持...
敏感脆弱的人是最容易掉泪的.
当然科学的说法就是泪腺发达,但这很主观,人总是很情绪化的,敏感脆弱的人富有同情心,心底善良者居多,最容易情绪化的表达情感.
女性爱哭有两种主要原因:
1. 因为女性大脑的情感中枢的结构,决定女性是感情细腻的,容易受伤的。
2. 一般来说,女性的生活经历中痛苦多、挫折多。
3. 社会常...
也许应该先去寻找快乐,而不是在痛苦的前提下不哭。
学习了解理解和关心,学习爱,得到爱
我也很爱哭啊,也是动不动就哭的那种!可哭也是一种发泄啊!,哭过就会坚强的!
自己高兴就好!
答: 我怀孕5个月了怎么晚上老失眠
答: 5、人们寻求心理咨询和心理训练的出发点是一致的,那就是体验到强烈的负面情绪
答: 你好,精神病指的是大脑机能活动发生絮乱,导致认识、情感、行为和意志等精神活动不同程度障碍的疾病的总称。致病因素有多方面:先天遗传、个性特征及体质因素、器质因素、...
答: 不知他是从小就这样的,还是长大后遇到什么事情改变的。如果是从小的我认为是偏执型人格障碍,这种病最好在小时候通过行为矫正来改善,一旦成人定型后会很难改变,但也不是...
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清华大学生命科学学院上目录导师简介
清华大学生命科学学院上目录导师简介(44人)
  陈国强 教授,博士生导师2
  陈晔光 教授、博士生导师3
  陈应华 博士教授,长江特聘教授4
  高海啸 博士教授 博士生导师5
  高宁 博士生导师7
  龚海鹏 副教授,博士生导师7
  李蓬 博士,教授 清华大学生命科学学院副院长8
  刘栋 教授9
  刘进元 博士教授 博士生导师 中国农业生物化学与分子生物学分会副理事长10
  刘玉乐 博士教授,百人教授,国家杰出青年基金获得者,博士生导师12
  罗弘 博士 教授 博士生导师13
  罗永章 博士教授,博士生导师,长江学者特聘教授,国家杰出青年基金获得者14
  雷建林 博士教授 博士生导师15
  孟安明 博士教授,博士生导师,长江特聘教授,国家杰出青年基金获得者中科院院士16
  潘俊敏 博士 教授,博士生导师18
  潘宪明 博士 教授,博士生导师,国家杰出青年基金获得者19
  施一公 博士 教授,博士生导师,长江讲座教授,国家杰出青年基金获得者20
  隋森芳 博士 教授 博士生导师21
  陶庆华 博士 教授,博士生导师23
  王志新教授、院士,博士生导师24
  王新泉 博士 教授  博士生导师25
  吴嘉炜教授、博士生导师26
  吴庆余 教授,博士生导师,国家杰出青年基金获得者,首届国家教学名师奖获得者27
  吴 畏 教授,博士生导师28
  谢道昕 博士教授,博士生导师,教育部长江学者特聘教授,国家杰出青年基金获得者29
  闫永彬 博士,副研究员,博士生导师31
  俞立 博士 教授 博士生导师32
  杨茂君 博士 教授 博士生导师33
  张大鹏 博士 教授 博士生导师34
  张荣庆 博士 教授 博士生导师35
  周 兵 博士 教授 博士生导师国家杰出青年基金获得者36
  程京 教授,博士生导师38
  王钊 博士,药理学与毒理学教授,博士生导师40
  张林琦 教授、博士生导师、长江特聘教授、国家杰出青年基金获得者41
  祁海 博士,特别研究员42
  刘国松 教授,博士生导师44
  孙方霖 教授,博士生导师,长江学者特聘教授,国家杰出青年科学基金获得者45
  常智杰 教授,博士生导师46
  杜力军 博士,教授,博士生导师47
  邢婉丽 研究员,博士生导师48
  颜宁  教授、博士生导师49
  吴励 教授,博士生导师50
  李海涛 博士,特别研究员51
  张敬仁 博士,特别研究员53
  陈国强 教授,博士生导师
  教育工作经历
  广州华南理工大学学士,
  奥地利格拉茨工业大学博士,
  英国诺丁汉大学,博士后,
  加拿大阿尔伯达大学,博士后,
  清华大学,副教授,
  清华大学,教授,1997-今
  研究领域及方向
  工业生物技术和合成生物学
  微生物合成高分子材料聚羟基脂肪酸酯(PHA)
  微生物代谢工程及微生物合成生物学
  PHA在微生物中生理作用的研究
   PHA作为组织工程材料的应用研究?
   PHA作为可降解材料和生物燃料的应用研究?
  共在国际学术期刊上发表文章140多篇,近年代表作如下:
  1.Chen GQ. A Polyhydroxyalkanoates Based Bio- and Materials Industry. Chem Soc Rev 2009, DOI:10.c
  2.Zhang XJ, Luo RC, Wang Z, Deng Y and Chen GQ. Applications of (R)-3-hydroxyalkanoate Methyl Esters Derived from Microbial Polyhydroxyalkanoates as Novel Biofuel. Biomacromolecules 10 (2009) 707&711
  3.Cai L, Yuan MQ, Liu F, Jian J and Chen GQ. Enhanced Production of Polyhydroxyalkanoates by PHA depolymerase knockout mutant of Pseudomonas putida KT2442. Bioresource Technol. 100 (2009)
  4.Zou XH, Li HM, Wang S, Leski M, Yao YC, Yang XD, Huang QJ and Chen GQ. The Effect of 3-Hydroxybutyrate Methyl Ester on Learning and Memory in Mice. Biomaterials 30 (2009)
  5.Shen XW, Yang Y, Jian J, Wu Q and Chen GQ. Production and Characterization of Homopolymer poly(3-hydroxyvalerate) (PHV) Accumulated by Wild type and Recombinant Aeromonas hydrophila Strain 4AK4. Bioresource Technol 100 (2009)
  6.Chung A, Liu Q, Ouyang SP, Wu Q and Chen GQ. Microbial production of 3-hydroxydodecanoic acid by pha-operon and fadBA knockout mutant of Pseudomonas putida KT2442 harboring tesB gene. Appl Microbiol Biotechnol 83 (2009) 513 & 519
  7.Wang ZH, Wu HN, Chen J, Zhang J and Chen GQ. A novel self-cleaving phasin tag for purification of recombinant proteins based on hydrophobic nanoparticles. Lab on a Chip 8 (2008) 1957-62
  8.Chen GQ, Wu Q. Microbial Production and Applications of Chiral Hydroxyalkanoates. Appl Microbiol Biotechnol 67 (2005) 592 & 599
  9.Chen GQ and Wu Q. Polyhydroxyalkanoates as Tissue Engineering Materials. Biomaterials 26 (2005)
  10.Zheng Z, Gong Q, Liu T, Deng Y, Chen JC and Chen GQ. Thioesterase II of Escherichia coli plays an important role in 3-hydroxydecanoic acid production. Appl Environ Microbiol 70 (2004):
  联系方式:
  清华大学生命科学学院微生物实验室,北京100084
  电话:+86-10-;传真:+86-10-
  E-mail: chengq@mail.
  陈晔光 教授、博士生导师
  教育工作经历:
  ,就读于江西大学生物系,获生物学学士学位。
  ,就读于江西大学生物系,获动物学硕士学位。
  ,就读于Fordham University,获细胞生物学硕士学位。
  ,就读于美国Albert Einstein College of Medicine,获Ph.D.学位
  , Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute.
  , Assistant Professor, University of California, Riverside.
  2002-至今,清华大学教授。
  研究兴趣、领域
  细胞信号转导:利用膜生物学、分子生物学、生物化学、细胞生物学和发育生物学等多学科技术手段研究TGF-&和Wnt信号的调控以及它们在器官发育、干细胞自我更新和分化、肿瘤形成中的作用。
  开设的课程:《细胞生物学》、《细胞信号转导与疾病的发生》、《肿瘤生物学专题讨论》
  代表性论文:
  1.Zuo W, Chen YG# 2009 Specific activation of MAPK by TGF-& receptors in lipid rafts is required for epithelial cell plasticity. Molecular Biology of the Cell, 20:.
  2.Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG#. 2008 Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. Journal of Biological Chemistry, 283:.
  3.Zhao X, Nicholls JM, Chen YG# 2008 SARS-CoV nucleocapsid protein interacts with Smad3 and modulates TGF-& signaling. Journal of Biological Chemistry, 283:.
  4.Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG# 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.
  5.Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG# 2008 The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/&-catenin signaling. Journal of Biological Chemistry, 283:.
  6.Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-&-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.
  7.Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG# 2007 Smad7 antagonizes TGF-& signaling in the nucleus by interfering with functional Smad-DNA complex formation. Molecular and Cellular Biology, 27:.
  8.Chen YG#, Wang Z, Ma J, Zhang L, Lu Z 2007 Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-& signaling. Journal of Biological Chemistry, 282:.
  9.Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG# 2006 Functional analysis of mutations in the kinase domain of the TGF-& receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood, 107:.
  10.Zhang L, Gao X, Wen J, Ning Y, Chen YG# 2006 Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation. Journal of Biological Chemistry, 381:.
  11.Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117
  12.Lu, Z., Murray, J. T., Luo, W., Li, H., Wu, X., Xu, H., Backer, J. M. and Chen, Y.G# 2002 Transforming growth factor-& activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:.
  13.Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagu& J, Shi Y. 2000 Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97.
  14.Onichtchouk, D*, Chen, YG*, Dosch, R., Gawantka, V., Delius, H., Massagu&, J. and Nierhs, C. 1999 Silencing of TGF-& signaling by the pseudoreceptor BAMBI. Nature, 401:480-485.
  荣誉、奖励及参加学术团体的情况
  2008年何梁何利科学与技术进步奖
  2008年清华大学生物科学与技术系&东胜创新成就奖&
  2007年&新世纪百千万人才工程&
  2006年中国青年科技奖
  2004年教育部&中国高等学校十大科技进展&
  年度美国&李氏基金杰出成就奖&
  2002年国家&杰出青年基金&获得者
  2002年教育部&长江学者奖励计划&特聘教授
  联系方式:
  北京市清华大学生命科学学院,分子细胞学实验室  100084
  电 话:010-;传 真:010-
  E-mail:ygchen@mail.
  陈应华 博士教授,长江特聘教授
  国家杰出青年基金获得者,香港求是科技基金会&杰出青年学者奖&获得者
  教育工作经历
   武汉大学学士(病毒学)
   德国慕尼黑大学博士(免疫学)
   德国慕尼黑大学免疫学研究所工作
   奥地利因斯布鲁克大学正式工作职位(课题组长)
  1996-至今 回国工作 清华大学教授
  主要科研领域与方向:
  艾滋病病毒基础研究;病毒表位疫苗作用机理研究;重组表位疫苗的设计与应用基础研究
  代表性论文
  1.Lu L, Zhu Y, Huang JH, Chen X, Yang HW, Jiang SB, Chen YH. Surface exposure of the HIV-1 Env cytoplasmic tail LLP2 domain during the membrane fusion process - Interaction with gp41 fusion core. Journal of Biological Chemistry.2008, 283(24):.
  2.Huang JH, Qi Z, Wu F, Kotula L, Jiang SB, Chen YH. Interaction of HIV-1 gp41 core with NPF motif in Epsin - Implication in endocytosis of HIV. Journal of Biological Chemistry. 2008, 283(22):.
  3.Li J, Chen X, Jiang SB, Chen YH. Deletion of fusion peptide or mutation-induced disruption of the HIV-1 gp41 core structure resulting in increased antigenicity and immunogenicity of 4E10 epitope. Biochemical and Biophysical Research Communications : 60-64.
  4.Lu L, Zhu Y, Diao JC, Wang ZG, Chen YH. V3CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8(+) T cells. Vaccine.2008, 28(6):845-852.
  5.Huang JH, Lu L, Lu H, Chen X, Jiang S, Chen YH. Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1. Journal of Biological Chemistry. 2007, 282: . 
  6.Huang JH, Yang HW, Liu S, Jiang S, Chen YH. The mechanism by which molecules containing the HIV-1 gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium-formation. Biochemical Journal.2007, 403: 565-571
  7.J.H. Huang, Z.Q. Liu, S. Liu, S.Jiang, Y.H. Chen. Identification of the HIV-1 gp41 core-binding motif-HXXNPF. FEBS Letters. 2006, 580:
  8.Wanli Liu, Ying-Hua Chen. High epitope density in single protein molecule significantly enhanced antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins. European Journal of Immunology. 2005, 35:505-14.
  9.Wanli Liu, Peng Zou, Jian Ding, Yun Lu, Ying-Hua Chen. Sequence comparison of the extracellular domain of M2 protein between human and avian influenza a virus provides new information for bivalent influenza vaccine design. Microbes Infect. 2005, 7:171-177
  10.Dong XN, Chen X, Chen Y, Ablimit A, Ye Z, Wu Y, Ying-Hua Chen. Short Communication: HIV Type 1 Phenotype, Tropism, and Sequence Patterns: Association and Preference. AIDS Res Hum Retroviruses. 2005, 21:234-8
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail:chenyh@
  高海啸 博士教授 博士生导师
  教育工作经历
  1993年,兰州大学物理系理论物理专业学士
  1996年,北京工业大学物理系理论物理专业硕士
  2000年,中科院物理所晶体学专业博士
  , Howard Hughes Medical Institute,Wadsworth Center,Albany, New York, Research Associate
  , Health Research Inc,Wadsworth Center, Albany, New York, Research Scientist
  2008-至今 清华大学生命科学学院教授, &百人计划&引进人才
  主要科研领域与方向:
  基于冷冻电子显微学(cryo-electron microscopy)的生物大分子复合体结构和功能的研究
  三维重构(three-dimensional reconstruction)核心算法和图像分析研究
  代表性论文
  1.Shaikh,T.R., Gao, H, Baxter, W.T., Asturias, F.J., Boisset, N., Leith, A., Frank, J. (2008) SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat. Protoc. 3,.
  2.Frank, J., Gao, H., Sengupta, J., Gao, N., and Taylor, D. (2007) The process of mRNA-tRNA translocation. Proc. Natl. Acad. Sci. (USA). 104,.
  3.Gao, H., Zhou, Z., Rawat, U., Huang, C., Bouakaz, L., Wang, C., Cheng, Z., Liu, Y., Zavialov, A., Gursky,R., Sanyal, S., Ehrenberg, M., Frank, J., and Song, H. (2007) RF3 induces ribosomal conformational changes responsible for dissociation of class-I release factors. Cell 129, 929-941.
  4.Scheres, S., Gao, H., Valle, M., Herman, G.T., Eggermont, P.P.B., Frank, J., and Carazo, J.M. (2007) Disentangling conformational states of macromolecules in three-dimensional cryo-EM through likelihood optimization. Nat. Methods 4, 27-29.
  5.Fu J, Gao H, Frank J. (2007) Unsupervised classification of single particles by cluster tracking in multi-dimensional space. J.Struct. Biol. 157,226-239.
  6.Rawat U, Gao H, Zavialov A, Gursky R, Ehrenberg M, Frank J.(2006) Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J. Mol. Biol. 357,.
  7.Gao, H., Juri Ayub, M., Levin, M.J., and Frank, J. (2005) Structure of the 80S ribosome from Trypanosoma cruzi reveals novel rRNA components. Proc. Natl. Acad. Sci. (USA). 102, .
  8.Gao, H., and Frank, J. (2005) Molding atomic structures into intermediate-resolution cryo-EM density maps of ribosomal complexes using real-space refinement. Structure 13, 401-406.
  9.Gao, H., Valle, M., Ehrenberg, M., and Frank, J. (2004) Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset. J. Struct. Biol. 147, 283-290.
  10.Gao, H., Sengupta, J., Valle, M., Korostelev, A., Eswar, N., Stagg, S.M., van Roey, P., Harvey, S.C., Agrawal, R.K., Sali, A., Chapman, M.S., and Frank, J. (2003) Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell 113, 789-801.
  11.Gao, H., Spahn, C.M.T., Grassucci, R.A., and Frank, J. (2002) An assay for local quality in cryo-electron micrographs of single particles. Ultramicroscopy 93, 169-178.
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail:hxgao@mail.
  高宁 博士生导师
  教育工作经历
  2000 学士 北京大学生物化学及分子生物学系
  2006 博士 纽约州立大学Albany分校生物医学
   博士后 Howard Hughes Medical Institute, Wadsworth Center, and Columbia University Medical Center
  2008年底 副教授 清华大学生命科学学院结构生物学中心
  研究兴趣 
  运用冷冻电镜三维重构技术和生物化学及分子生物学手段进行生物大分子复合物的结构与功能研究。
  代表性论文
  1.Gao N, Zavialov AV, Li W, Sengupta J, Valle M, Gursky RP, Ehrenberg M and Frank J. (2005) Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies. Molecular Cell, 18:663-674. 
  2.Gao N and Frank J. (2006) A library of RNA bridges (News and Views). Nature Chemical Biology, 2:231-232.
  3.Frank J, Gao H, Sengupta J, Gao N and Taylor D. (2007) The Process of mRNA-tRNA Translocation. Proceedings of the National Academy of Sciences of the United States of America, 104:.
  4.Gao N, Zavialov AV, Ehrenberg M, Frank J. (2007) Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits. Journal of Molecular Biology, 374:.
  联系方式:
  电话:
  E-mail:ninggao@
  龚海鹏 副教授,博士生导师
  教育工作经历
  年学士  清华大学生物科学与技术系
  年硕士  清华大学生物科学与技术系
  年 博士  Johns Hopkins University, Program of Molecular Biophysics
  年 博士后 Johns Hopkins University, Program of Molecular Biophysics
  年 博士后 University of Chicago, Department of Biochemistry and Molecular Biology
  2009年3月至今副教授 清华大学生命科学学院
  研究方向
  1.用统计和计算的方法研究蛋白质折叠的热力学、动力学和机理,以及蛋白质去折叠态的结构特征
  2.用分子动力学模拟研究生物大分子的动态和作用机理
  3.从序列预测蛋白质和RNA的三维结构
  代表性论文
  1.Gong H and Freed KF, Langevin-Debye model for non-linear electrostatic screening of solvated ions, Phys. Rev. Lett. 2009, 102(5): 057603.
  2.Gong H, Hocky GM, and Freed KF, Influence of nonlinear electrostatics on transfer energies between liquid phases: Charge burial is far less expensive than Born Model, Proc. Natl. Acad. Sci. U. S. A. 2008, 105(32): .
  3.Gong H and Rose GD, Assessing the solvent-dependent surface area of unfolded proteins using an ensemble model, Proc. Natl. Acad. Sci. U. S. A. 2008, 105(9): .
  4.Gong H, Shen Y, and Rose GD, Determining protein tertiary structure from backbone chemical shifts, Protein Sci. 2007, 16(8): .
  5.Fleming PJ, Gong H, and Rose GD, Secondary structure determines protein topology, Protein Sci. 2006, 15(8): .
  6.Gong H, Fleming PJ, and Rose GD, Building native protein conformation from highly approximate backbone torsion angles, Proc. Natl. Acad. Sci. U. S. A. 2005, 102(45): .
  7.Gong H, Isom DG, Srinivasan R, and Rose GD, Local secondary structure content predicts folding rates for simple, two-state proteins, J. Mol. Biol. 2003, 327(5): .
  联系方式:
  电话:010-
  E-mail: hgong@
  李蓬 博士,教授 清华大学生命科学学院副院长
  教育工作经历:
  北京师范大学学士,1983 - 1987
  美国加州大学圣地亚哥分校博士,1992 - 1995
  新加坡国立大学分子与细胞生物学研究所,博士后,
  美国达拉斯德州大学西南医学中心Howard Hughes医学研究所,博士后,1996 - 1997
  新加坡分子和细胞生物学研究所,助理教授及研究室主任,
  香港科技大学生物系,助理教授&副教授(获终身制),
  清华大学生命科学学院,长江学者特聘教授,2006-至今
  研究兴趣、领域
  代谢性疾病如肥胖症,糖尿病,动脉粥样硬化等的发生和发展机制,主要研究脂肪细胞和肝细胞中的脂肪积累,分泌及分解的分子机制以及与胰岛素敏感性的关系。在细胞水平上研究线粒体的功能,脂滴的形成,融合及与内质网的关系。
  已发表40余篇具有较高影响因子的国际论文,其中最具代表性的论文如下:
  1.J Ye, J Z Li, Y Liu, X Li, T Yang, X Ma, Q Li, Z Yao, P Li. Cideb, an ER and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metabolism, 9(2):177-190;2009 (通讯作者)
  2.J Qi, J Gong, T Zhao, J Zhao, P Lam, J Ye, JZ Li, J Wu, HM Zhou, and P Li. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO. J. 27(11):08 (通讯作者)
  3.JZ Li, J Ye, B Xue, J Qi, J Zhang, Z Zhou, Q Li, Z Wen, and P Li. Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogenesis and fatty acid oxidation, Diabetes, 56(10):07 (通讯作者)
  4.Z Zhou, SY Toh, Z Chen, K Guo, C P. Ng, S.Ponniah, SC Lin, W. Hong, and P.Li .CIDE-A deficient mice exhibit lean phenotype and are obesity resistant. Nature Genetics 35: 49-56, 2003(通讯作者)
  5.P Li, D. Nijhawan, I.Budihardio, SM. Srinivasula, M.Ahmad, ES. Alnemri, and X.Wang, Cytochrome C and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91:478-489, 1997(第一作者)
  联系方式:
  通信地址:北京市海淀区清华大学生命科学学院(100084)
  电话:010-
  Email:li-peng@mail.
  Fax:86-10-
  刘栋 教授
  教育工作经历:
  华东师范大学学士,1984年
  中国科学技术大学,硕士,1987年
  美国普渡大学,博士,1994年
  中国科学院上海植物生理研究所,助理研究员,年
  博士后?美国加州大学圣地亚哥分校,
  美国Dow AgroSciences公司,资深研究员,年
  清华大学,教授, 2005-现在
  研究兴趣、领域:
  植物对低磷胁迫反应的信号转导机制
  调控植物根系发育的分子基础
  植物基因工程
  代表性论文:
  1.Liu, D. Design of gene constructs for transgenic maize. In: Transgenic Maize (Methods in Molecular Biology, Vol. 256) (2009), Humana Press, pp3-30. (Book chapter)
  2.Yuan, H.and Liu, D. Signaling components invovled in plant responses to phosphate starvation. (2008) J. Integr. Plant Biol. 50(7):849-859.
  3.Liu, D., Burton, S., Glancy, Todd., Li, S., Hampton, R., Meade, M., and Merlo, D. (2003) Insect resistance conferred by 283-kDa Photorhabdus luminescens protein TcdA in Arabidopsis thaliana. Nature Biotechnology, 21(10):1222-8.
  4.Liu, D., Wang, R., Galli, M., and Crawford, N. (2001)Somatic and germinal excision activities of the Arabidopsis transposon Tag1 are controlled by distinct regulatory sequences within Tag1. Plant Cell, 13(8):1851-63.
  5.Liu, D., Galli, M., and Crawford, N. (2001) Engineering variegated floral patterns in tobacco plants using the Arabidopsis transposable element Tag1. Plant and Cell Physiology, 42(4):419-23. (Cover story)
  6.Liu, D., Mack, A., Wang, R., Galli, M., Belk, J., Ketpura, N., and Crawford, N. (2001) Functional dissection of the cis-acting sequences of the Arabidopsis transposable element Tag1 reveals dissimilar subterminal sequence and minimal spacing requirements for transposition. Genetics, 157 (2):817-30.
  7.Liu, D., Zhang, S., Fauqet, C., and Crawford, N. (1999) The Arabidopsis transposon Tag1 is active in rice, undergoing germinal transposition and restricted, late somatic excision.Molecular and General Genetics, 262(3):413-20.
  8.Liu, D., and Crawford, N.M. (1998)Characterization of the putative transposase mRNA of Tag1, which is ubiquitously expressed in Arabidopsis and can be induced by Agrobacterium-mediated transformation with dTag1 DNA. Genetics, 149: 693-701.
  9.Liu, D.,and Crawford, N.M. (1998) Characterization of the germinal and somatic activity of the Arabidopsis transposable element Tag1.Genetics, 148: 445-456.
  10.Frank, M.J., Liu, D., Tsay, Y.-F.,Ustach, C., and Crawford, N.M. (1997) Tag1 is an autonomous transposable element that shows somatic excision in both Arabidopsis and tobacco. Plant Cell, 9: .
  荣誉、奖励
  所授《生物化学》(1)入选2007年北京市精品课程。?
  联系方式:
  北京市海淀区清华大学生命科学学院 100084
  电话: 010-
  Fax: 010-
  Email: liu-d@mail.
  刘进元 博士教授 博士生导师 中国农业生物化学与分子生物学分会副理事长
  教育工作经历
  1992-现在 清华大学教授
   东京大学访问教授
   John Innes Centre 访问教授
   北京大学副教授
   东京农工大学博士
   南京农业大学学士
  主要科研领域与方向
  本实验室致力于植物细胞应答过氧化氢的分子机制研究。目前的研究重点:1)植物细胞应答过氧化氢的蛋白质及miRNA的双色网络的构建;2)重要功能蛋白质及miRNA在植物细胞应答过氧化氢反应中的作用解析;3)植物磷酸化蛋白质组及碱性蛋白质分析的方法创新。
  代表性论文(*corresponding author)
  1.Xiang-Yuan Wan and Jin-Yuan Liu* (2008) Comparative proteomic analysis reveals an intimate protein network provoked by hydrogen peroxide stress in rice seedling leaves. Molecular and Cellular Proteomics 7: .
  2.Yi-Wei Yang, Shao-Min Bian, Yuan Yao and Jin-Yuan Liu* (2008) Comparative proteomic analysis provides new insights into the fiber elongating process in cotton. Journal of Proteome Research. 7: .
  3.Bo Huang, Long-Guo Jin and Jin-Yuan Liu* (2008) Identification and characterization of the novel gene GhDBP2 encoding a DRE-binding protein from cotton (Gossypium hirsutum) Journal of Plant Physiology 165(2):214-223.
  4.Xueping Wu, Yongsheng Cheng, Jin-Yuan Liu* (2007) Microwave enhanced ink staining for fast and sensitive protein quantitation in proteomic study. Journal of Proteome Research 6(1):387-391.
  5.Saleem A. Bokhari, Xiang-Yuan Wan, Yi-Wei Yang, Lu Zhou, Wan-Li Tang and Jin-Yuan Liu* (2007) Proteomic response of rice seedling leaves to elevated CO2 levels. Journal of Proteome Research 6: .
  6.Ai-Min Wu, Shi-You L&, Jin-Yuan Liu* (2007) Functional analysis of a cotton glucuronosyltransferase promoter in transgenic tobacco plants. Cell Research 17(2):174-183.
  7.Shiyou L&, Hongya Gu, Xiaojing Yuan, Xiaoming Wang, Aiming Wu, Li-Jia Qu, Jin-Yuan Liu* (2007) The GUS reporter-aided analysis of the promoter activities of a rice metallothionein gene reveals different regulatory regions responsible for tissue-specific and inducible expression in transgenic Arabidopsis. Transgenic Research 16:177-191.
  8.Yuan Yao, Ying Du, Lin Jiang and Jin-Yuan Liu* (2007) Interaction between ACC synthase 1 and 14-3-3 proteins in Rice: a new insight. Biochemistry (Moscow) 72 (9): .
  9.Yuan Yao, Yi-Wei Yang and Jin-Yuan Liu* (2006) An efficient protein preparation for proteomic analysis of developing cotton fibers by two-dimensional gel electrophoresis. Electrophoresis 27: .
  10.Xiao-Dong Yang, Chun-Juan Dong, Jin-Yuan Liu* (2006) A plant mitochondrial phospholipid hydroperoxide glutathione peroxidase: its precise localization and higher enzymatic activity. Plant Mol Biol 62:951-962.
  11.Bo Huang, Jin-Yuan Liu* (2006) A cotton dehydration responsive element binding protein functions as a transcriptional repressor of DRE element-mediated gene expression.Biochem Biophys Res Comm 343:.
  12.Suxia Cui, Fang Huang, Jie Wang, Xiao Ma, Yongsheng Cheng, Jin-Yuan Liu* (2005) A proteomic analysis of cold stress responses in rice seedlings. Proteomics 5:
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail:liujy@mail.
  Web: http://molgene.biosci.
  刘玉乐 博士教授,百人教授,国家杰出青年基金获得者,博士生导师
  教育工作经历:
  8.7  天津南开大学生物化学专业 (学士)   
  2.6  北京中国科学院微生物学研究所 (硕士)  
  7.11  中国科学院微生物学研究所与英国苏格兰作物研究所联合培养博士
  8.9  北京中国科学院微生物学研究所 实习,助理,副研究员,研究员
  6.5  英国苏格兰作物研究所   访问学者
  9.8  美国德克萨斯大学奥斯丁分校  博士后
  2.8  美国耶鲁大学     博士后
  6.12  美国耶鲁大学    Associate Research Scientist
  2007.1 ---至今   清华大学     教授,&百人计划&责任教授
  研究方向:
  植物免疫的信号传导与调控
  植物病毒病理的分子基础
  植物功能基因组
  学术荣誉:
  1997年,中国科学院青年科学家奖获得者
  2007年,国家杰出青年基金获得者
  2007年,清华大学&百名人才引进计划& 责任教授
  代表性论文:
  1.Liu Y, Schiff M, Czymmek K, Talloczy Z., Levine B and Dinesh-kumar SP. Autophagy regulates programmed cell death during the plant innate immune response, Cell, 121(4), 567-577, 2005
  2.Burch-Smith T*, Schiff M*, Liu Y*, and Dinesh-Kumar SP, Efficient virus induced gene silencing in Arabidopsis thaliana, Plant Physiology, 142(1):21-27, 2006 (*co-first author)
  3.Liu Y*, Burch-Smith T*, Schiff M, Feng S, Dinesh-Kumar SP. Molecular Chaperone Hsp90 Associates with Resistance Protein N and Its Signaling Proteins SGT1 and Rar1 to Modulate an Innate Immune Response in Plants. Journal of Biological Chemistry, 279(3): 2101-8, 2004 (*contributed equally)
  4.Liu Y*, Nakayama N*, Schiff M, Litt A, Irish VF and Dinesh-Kumar SP, Virus-induced silencing of a DEFICIENS ortholog in Nicotiana benthamiana, Plant Molecular Biology, 54(5), 701-711, 2004, (*contributed equally)
  5.Liu Y, Schiff M, Dinesh-Kumar SP, Functional requirement of A MAPK cascades, WRKY/MYB1 transcription factors, COI1 and CTR1 in N-mediated resistance to tobacco mosaic virus, Plant Journal 38(5), 800-809, 2004
  6.*Bilgin D, *Liu Y , Schiff M, Dinesh-Kumar S. P, P58IPK, a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Developmental Cell, 4, 651-661, 2003 (*contributed equally)
  7.Xie Y, Liu Y*, Meng M, Chen L and Zhu Z*. Isolation and identification of a super strong plant promoter from cotton leaf curl Multan virus, Plant Molecular biology, Plant Molecular Biology 53(1), 1-14, 2003 (*corresponding author)
  8.Liu Y, Schiff M, Serino G, Deng X-W and Dinesh-Kumar S. P, Role of SCF ubiqutin-ligase and the COP9 signalosome in the N-mediated resistance to tobacco mosaic virus, Plant Cell 14(7), , 2002
  9.Liu Y, Schiff M, Marathe R. and Dinesh-kumar. Tobacco Rar1, EDS1 and NPR1/NIM1 like genes are required for N-mediated resistance to tobacco mosaic virus. Plant Journal 30(4): 415-29, 2002.
  10.Liu Y, Schiff M, Dinesh-Kumar S. P. Virus-induced gene silencing in Tomato, Plant Journal 31(6), 777-786, 2002
  11.Liu Y, Robinson DJ, Harrison BD, Defective forms of cotton leaf curl virus DNA-A that have different combinations of sequence deletion, duplication, inversion and rearrangement, Journal of General Virology, 79:1501-8, 1998
  联系方式:
  电话:+86-10-
  E-mail: yuleliu@mail.
  罗弘 博士 教授 博士生导师
  教育工作经历
  1982年,湖南农业大学学士
  1987年,湖南农业大学硕士
  1992年,路易维尔大学博士
  ,Post-doctoral Fellow,Dana-Farber Cancer Institute, Boston
  ,Post-doctoral Fellow,Massachusetts General Hospital, Boston
  ,Assistant Biologist,Massachusetts General Hospital, Boston
  ,Assistant Professor,Texas A&M University College of Medicine
  2004-至今, 清华大学教授
  研究兴趣、领域
  果蝇大脑的发育神经生物学。(1)JAK/STAT信号途径在果蝇大脑发育中的作用;(2)Notch信号途径在果蝇大脑发育中的作用;(3)细胞极性因子、肿瘤抑制基因在神经干细胞维持中的作用。
  代表性论文
  1.Luo H, Hanratty WP, and Dearolf CR. 1995. An amino acid substitution in the Drosophila HopTum-l Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 14: .
  2.Yan RQ, Luo H, Darnell JE, and Dearolf CR. 1996. A JAK-STAT pathway regulates wing vein formation in Drosophila. Proc. Natl. Acad. Sci. USA. 93: .
  3.Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, DAndrea AD, and Dearolf CR. 1997. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell. Biol. 17: .
  4.Luo H, Asha H, Kockel L, Parke T, Mlodzik M, and Dearolf CR. 1999. The Drosophila Jak kinase Hopscotch is required for multiple developmental Processes in the eye. Dev. Biol. 213: 432-441.
  5.Luo H and Dearolf CR. The JAK/STAT pathway and Drosophila development. 2001. BioEssays 23: .
  6.Luo H, Rose PE, Roberts TM, and Dearolf CR. 2002. The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and Differentiation in Drosophila. Mol. Genet. Genomics 267: 57-63.
  荣誉、奖励、资助
  , Special Fellow, Leukemia and Lymphoma Society of America, $110,000
  , Principal Investigator, Signaling Mechanisms of the Drosophila JAK/STAT Pathway, NIH R01GM67019-01, $1,280,400
  (Declined in 2004)
  联系方式:
  北京市海淀区清华大学生命科学学院 100084
  电话:86-10-
  E-mail: luohong@mail.
  罗永章 博士教授,博士生导师,长江学者特聘教授,国家杰出青年基金获得者
  教育工作经历
  1985年,兰州大学化学系物理化学专业 学士
  1989年,美国田纳西州大学诺克斯维尔分校生物化学系生物化学专业 硕士
  1993年,美国加州大学伯克利分校分子与细胞生物学系生物化学专业 博士
  主要科研领域与方向:
  1. 新生血管生成调控的分子机理
  2. 肿瘤转移的分子机理
  3. 蛋白质错误折叠疾病
  代表性论文
  1.Yujie Huang, Nan Song, Yanping Ding, Shaopeng Yuan, Xuhui Li, Hongchen Cai, Hubing Shi, Yongzhang Luo (2009). &Pulmonary vascular destabilization in the pre-metastatic phase facilitates lung metastasis& Cancer Research (In press)
  2.Nan Song, Yujie Huang, Hubing Shi, Shaopeng Yuan, Yanping Ding, Xiaomin Song, Yan Fu, Yongzhang Luo (2009) &Overexpression of Platelet-Derived Growth Factor-BB Increases Tumour Pericyte Content via Stromal-Derived Factor-1&/CXCR4 Axis& Cancer Research 69, .
  3.Yan Fu, Huadong Tang, Yujie Huang, Nan Song and Yongzhang Luo (2009) &Unravel the Mysteries of Endostatin& IUBMB Life 61, 613&626.
  4.Huadong Tang, Yan Fu, Shunli Zhan, Yongzhang Luo (2009). &Alpha EC, the C-terminal extension of fibrinogen has chaperone-like activity& Biochemistry 48, .
  5.Shaopeng Yuan, Yan Fu, Xiaofeng Wang, Hubing Shi, Yujie Huang, Xiaomin Song, Ling Li, Nan Song, & Yongzhang Luo (2008). &Voltage dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis& The FASEB Journal 22, .
  6.Hubing Shi, Yujie Huang, Hao Zhou, Xiaomin Song, Shaopeng Yuan, Yan Fu, & Yongzhang Luo (2007). &Nucleolin is a Receptor that Mediates Antiangiogenic and Anti-tumor Activity of Endostatin& Blood (Featured in Cover) 110, .
  7.Comment on Shi et al, page 2899, by Judah Folkman (2007).
  8.&Endostatin finds a new partner: nucleolin& Blood 110, .
  9.Yujie Huang, Hubing Shi, Hao Zhou, Xiaomin Song, Shaopeng Yuan & Yongzhang Luo (2006). &The angiogenesis function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin& Blood 107, .
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail:protein@
  Web: http://www.luolab.org
  雷建林 博士教授 博士生导师
  教育工作经历
  1993年武汉大学物理系物理学专业 学士
  1998年武汉大学物理系凝聚态物理专业 博士
   中国科学院物理所 博士后
   Visiting Scholar, Institute of Crystallography, Ludwig-Maximilians-Universit&t M&nchen
   Research Affiliate, Wadsworth Center, New York State Department of Health
  2008 Associate Research Scientist, Department of Biochemistry and Molecular Biophysics, Columbia University
  2008年底清华大学生命科学学院 教授
  主要研究方向:
  基于三维重构的高通量自动化电子显微术。
  运用冷冻电镜技术进行生物大分子结构和功能的研究。
  代表性论文:
  1.Agirrezabala, X., Lei, J., Brunelle, J., Ortiz-Meoz, R., Green, R., and Frank, J. (2008). Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome. Molecular Cell 32, 190&197.
  2.Li, W., Agirrezabala, X., Lei, J., Bouakaz, L., Brunelle, L., Ortiz-Meoz, R., Green, R., Sanyal, S., Ehrenberg, M. and Frank, J. (2008). Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. The EMBO Journal 27, .
  3.Lei, J., and Frank, J. (2005). Automated acquisition of cryo-electron micrographs for Single particle reconstruction on an FEI Tecnai electron microscope. Journal of Structural Biology 150, 69&80.
  4.Weidner, E., Frey, F., Lei, J., Pedersen, B., Paulmann, C., and Morgenroth, W. (2004). Disordered quasicrystals: diffuse scattering in decagonal Al-Ni-Fe. J. Appl. Cryst. 37, 802-807
  5.Weidner, E., Lei, J., Frey, F., Wang, R., and Grushko, B. (2002). Diffuse scattering in decagonal Al&Ni&Fe. Journal of Alloys and Compounds 342, 156-158.
  6.Lei, J., Wang, R., Yin, J., and Duan, X. (2002). Diffuse electron scattering determination of elastic constants of Al&Pd&Mn icosahedral quasicrystal. Journal of Alloys and Compounds 342, 326-329.
  7.Wang, R., Hu, C., Lei, J. (2001). Theory of diffuse scattering of quasicrystals due to fluctuations of thermalised phonons and phasons. Phys. Stat. Sol. (b) 225, 21-34.
  8.Lei, J., Wang, R., Hu, C., and Ding, D. (2000). Diffuse scattering from dodecagonal quasicrystals. Eur. Phys. J. B 13, 21-30.
  9.Wang, R., Hu, C., Lei, J., and Ding, D. (2000). Theoretical aspects of thermal diffuse scattering from quasicrystals. Phys. Rev. B 61, .
  10.Lei, J., Wang, R., Hu, C., and Ding, D., (1999). Diffuse scattering from decagonal quasicrystals. Phys. Rev. B 59, 822-828.
  11.Lei, J., Hu, C., Wang, R., and Ding, D., (1999). Diffuse scattering from octagonal quasicrystals. J. Phys.: Condens. Matter 11, .
  12.Lei, J., Wang, R., Hu, C., and Ding, D. (1998). Diffuse scattering from pentagonal quasicrystals. Phys. Lett. A 247, 343-352.
  13.Wang, J., Lei, J., and Wang, R. (1998). Diffraction pattern calculation and phase identification of hypothetical crystalline C3N4. Phys. Rev. B 58, .
  联系方式
  电话: +86-10-
  传真: +86-10-
  E-mail: jllei@
  孟安明 博士教授,博士生导师,长江特聘教授,国家杰出青年基金获得者 中科院院士
  教育工作经历
  ,西南农业大学学士
  ,英国诺丁汉大学博士
  ,中国农业大学博士后、副教授
  ,美国佐治亚医学院访问学者
  1998至今,清华大学教授
  主要科研领域与方向:
  脊椎动物胚胎的分子发育生物学。主要利用斑马鱼做模式动物,分离克隆Nodal和FGF等信号通路的新的介导因子和调节因子,结合分子生物学、细胞生物学、遗传学等技术,研究它们在胚胎发育中的作用及其作用机制。利用诱变技术,鉴定影响早期胚胎发育的母源因子。
  学术荣誉与奖励:
  2008年当选发展中国家科学院(原第三世界科学院)院士;2007年当选中国科学院院士;2007年获得何梁何利基金科学与技术进步奖;2006年入选国家&新世纪百千万人才工程国家级人选&;2002年被评为教育部&全国高等学校优秀骨干教师&;2001年入选第四批教育部长江学者计划特聘教授;2000年入选教育部第二届&高校优秀青年教师教学科研奖励计划&;2000年入选教育部跨世纪优秀人才培养计划;2000年获得国家杰出青年基金;2000年获得香港求是科学技术基金会&杰出青年学者&奖(生物医学);1999年入选清华大学&百名人才引进计划&;1991年获第三届霍英东青年教师基金奖。
  现任第15届中国动物学会副理事长,中国细胞生物学会理士,Asia Pacific Developmental Biology Network (APDBN)组委会成员,Current Zoology主编,BMC Developmental Biology副主编,Journal of Cell Science、Journal of Biological Chemistry、Cell Research等杂志编委会成员;科技部&发育与生殖研究&重大科学研究计划专家组成员。
  代表性论文
  1.Zhang Y, Li X, Qi JJ, Wang J, Liu X, Zhang H, Lin SC, Meng AM. 2009. Rock2 controls TGF-beta signaling and inhibits mesoderm induction in zebrafish embryos. Journal of Cell Science, 122:.
  2.Jia SJ, Wu D, Xing CC, Meng AM. 2009. Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish.Developmental Biology, 333:273-284.
  3.Zhao L, Zhao XY, Tian T, Lu QL, Skrbo-Larssen N, Wu D, Kuang Z, Zheng XF, Han YC, Yang SY, Zhang CM, Meng AM. 2008. Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research, 80(2):200-208.
  4.Meng FW, Cheng X, Yang LL, Hou N, Yang X, Meng AM. 2008. Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response signaling. Journal of Cell Science, 121(17):.?to TGF-beta 
  5.Jia SJ, Ren Z, Li X, Zheng Y, Meng AM. 2008. smad2 and smad3 are required for mesendoderm induction by TGF-beta/Nodal signals in zebrafish. Journal of Biological Chemistry, 283(4):.
  6.Huang HZ, Lu F-I, Jia SJ, Meng S, Cao Y, Wang YQ, Ma WP, Yin K, Wen ZL, Peng JR, Thisse C, Thisse B, Meng AM. 2007. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development, 134(5): 979-988.
  7.Su Y, Zhang L, Gao X, Meng FW, Wen J, Zhou H, Meng AM, Chen YG. 2007. The evolutionally conserved activity of Dapper2 in antagonizing TGFbeta signaling. The FASEB Journal, 21(3):682-90.
  8.Rui RY, Xu Z, Xiong B, Cao Y, Lin SY, Zhang M, Chan SC, Luo W, Han Y, Lu ZL, Ye ZY, Zhou HM, Han JH, Meng AM, Sheng-Cai Lin. 2007. Abeta -catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida. Developmental Cell, 13(2):268-282.
  9.Xiong B, Rui YN, Zhang M, Shi KH, Jia SJ, Tian T, Yin K, Huang HZ, Lin SY, Zhao XG, Chen YH, Chen Y-G, Lin S-C, Meng AM. 2006. Tob1 controls dorsal development of zebrafish embryos by antagonizing maternalbeta-Catenin transcriptional activity. Developmental Cell, 11:225-238.
  10.Lin X, Duan XY, Liang Y-Y, Su Y, Wrighton KH, Long JY, Hu M, Davis CM, Wang JR, Brunicardi FCB, Shi YG, Chen Y-G, Meng AM, Feng X-H. 2006. PPM1A functions as a Smad phosphatase to terminate TGF-beta signaling. Cell, 125(5):915-928.
  11.Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen Y-G, Meng AM. 2004. Zebrafish Dpr2 inhibits mesoderm induction by promoting lysosomal degradation of Nodal receptors. Science, 306(5693):114-117.
  12.Cao Y, Zhao J, Sun ZH, Postlethwait J, Meng AM. 2004. fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Developmental Biology, 271(1):130-143.
  13.Penberthy WT, Zhao CT, Zhang Y, Jessen JR, Yang Z, Bricaud O, Collazo A, Meng A, Lin S. 2004. Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Developmental Biology, 275(1):225-234.
  14.Zhao J, Cao Y, Zhao CT, Postlethwait J, Meng AM. 2003. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EMBO Journal, 22(22): . 
  15.Zhao ZX, Cao Y, Li M, Meng AM. 2001. Injection of double-stranded RNA produces nonspecific defects in zebrafish. Developmental Biology, 229(1):215-223.
  16.Zhang LX, Hua ZC, Ren JG, Meng A. 2001. The nuclear localization signal of zebrafish terra is located within the DM domain. FEBS Letters, 503(1):25-29.
  17.Meng AM, Moore B, Tang H, Yuan BZ and Lin S. 1999. Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development, 126:. 
  18.Meng A, Tang H, Yuan BZ, Ong BA, Long Q, Lin S. 1999. Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1. Blood, 93(2):500-508.
  19.Meng A, Jessen J, Lin S. 1999. Transgenesis. Methods in Cell Biology, 60: 133-148.
  20.Jessen JR, Meng AM, Paw BH, Zon LI, Lin S. 1998. Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc. Natl. Acad. Sci. USA, 95:.
  21.Meng AM, Tang H, Ong BA, Farrell MJ, Lin S. 1997. Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc. Natl. Acad. Sci. USA, 94:.
  22.Long QM, Meng AM, Wang H, Jessen JR, Farrell MJ, Lin S. 1997. GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development, 124:.
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail:mengam@mail.
  潘俊敏 博士 教授,博士生导师
  教育工作经历:
  河北师范大学学士, 1986
  中国科学院水生所硕士,1989
  德国弗赖堡大学博士,1996
  美国西南医学中心,博士后,1999
  美国西南医学中心,Instructor,2001
  美国西南医学中心,Research Assistant Prof., 2006
  清华大学,教授, 博士生导师,2006
  研究兴趣、领域:
   信号传导与细胞骨架:纤毛或真核生物的鞭毛是基于细胞微管的一种亚细胞结构。它不仅起着细胞运动的作用,它还参与动物的发育、细胞分裂和维持各种器官的正常生理功能。纤毛的缺陷会导致多种疾病诸如呼吸道疾病、肾囊肿,内脏转位,肥胖症等。我们利用模式生物衣藻为材料,采用分子生物学、生物化学、细胞生物学等手段,研究纤毛的形成、解聚机理,运动功能、信号传导及在细胞分裂中的调控作用。由于纤毛的高度保守性,我们的研究成果适用于动物细胞的纤毛。我们的发现将对纤毛相关疾病的发病机理的认识、诊断和治疗提供理论上的支撑。
  微藻技术的开发和利用:进行微藻的培养,转基因技术和生物活性物质、生物再生能源的研究。
  代表性论文(2004年后):
  1.Piao tian, , Minna Luo, Liang Wang, Yan Guo,De Li, Peng Li, William J. Snell, Junmin Pan*. 2009. A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas. PNAS, 106,
(direct submission).
  2.Cao Muqing, Yu Fu, Yan Guo and Junmin Pan*. 2009. Chlamydomonas (Chlorophyceae) colony PCR. Protoplasma, 235, 107.
  3.Junmin Pan*. 2008. Cilia and ciliopathies: From Chlamydomonas and beyond. Sci China Ser C-Life Sci, 51, 479-486.
  4.Junmin Pan and William Snell. 2007. The primary cilum: Keeper of the key to cell division. Cell, 129, .
  5.Merchant S., &, Junmin Pan, et al., 2007. The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions. Science, 318, 245-250.
  6.Wang Q. Junmin Pan, and William Snell. 2006. A new role for intraflagellar transport: Intraflagellar transport particles participate directly in signal transduction during cilium-generated signaling in Chlamydomonas. Cell, 125, 549-562
  7.Junmin Pan and William Snell. 2005. Chlamydomonas shortens its flagella by activating disassembly, stimulating IFT particles and blocking anterograde cargo loading. Developmental Cell, 9, 431-438.
  8.Junmin Pan, Q. Wang, and William Snell. 2005. Cilium-generated signaling and cilia-related disorders. Laboratory Investigation, 85, 452-463.
  9.Junmin Pan, Qian Wang and William J. Snell. 2004. An Aurora Kinase Is Essential for Flagellar Disassembly in Chlamydomonas. Developmental Cell, 6: 445-451.
  10.William J. Snell, Junmin Pan and Qian Wang. 2004. Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to Human obesity disorders. Cell, 117, 693-697.
  联系方式:
  清华大学生命科学学院  100084
  电话/传真:010-
  E-mail:panjunmin@
  潘宪明 博士 教授,博士生导师,国家杰出青年基金获得者
  教育工作经历
  年,复旦大学学士
  年,北京大学硕士
  年,德国Bochum大学博士
  现任清华大学教授
  主要科研领域与方向:生物化学,蛋白质折叠和蛋白质结构预测。
  代表性论文
  1.Sheng X. R., Zhang H. J., Pan X. M. and Zhou J.M. (1997) Domain movement in rabbit muscle adenylate kinase might involve proline isomerization. FEBS Letters, 413, 429-432.
  2.Zhang H. J., Sheng X. R., Pan X. M.* and Zhou J.M. (1997) Activation of adenylate kinase by denaturatants is due to the increasing flexibility at its active sites. BBRC, 238, 382-386.
  3.Zhang H. J., Sheng X. R., Niu W. D., Pan X. M.* and Zhou J.M. (1998) Rabbit Muscle Adenylate Kinase: Evidence for at Least Two Native forms in Equilibrium in Aqueous Solution. J. Biol. Chem., 273, .
  4.Zhang H. J., Sheng X. R., Pan X. M.* and Zhou J. M. (1998) Refolding of urea-denatured adenylate kinase. Biochem. J., 333, 401-405.
  5.Sheng X. R., Li X. and Pan X. M.* (1999) An Iso-random Bi Bi mechanism for adenylate kinase. J. Biol. Chem., 274, .
  6.Li X. and Pan X. M.* (2001) New Method for accurate prediction of solvent accessibility from protein sequence. Proteins, structure, Function, and Genetics, 42, 1-5.
  7.Pan X. M.* (2001) Multiple linear regression for protein secondary structure prediction. Proteins, structure, Function, and Genetics. 43, 256-9
  8.Li X., Yang Han and Pan X. M.*(2001) Cysteine-25 of adenylate kinase reacts with dithiothreitol to form an adduct upon aging of the enzyme. FEBS Letters, 507 (2) 169-173.
  9.Han Y. , Li X. and Pan X. M.*(2002) Native States of adenylate kinase are two active sub-ensembles. FEBS Letter, 528 161-165
  10.Xu S., Qin S. and Pan X. M.* (2004)Thermal and Conformational Stability of Ssh10b Protein from Archaeon Sulfolobus shibattae. Biochem. J, 382, 433-440.
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail:pan-xm@mail.
  施一公 博士 教授,博士生导师,长江讲座教授,国家杰出青年基金获得者
  教育工作经历
   清华大学生物科学与技术系,学士
   美国约翰霍普金斯大学医学院,分子生物物理学博士
  1995  美国约翰霍普金斯大学医学院,博士后
   美国史隆凯特林癌症研究中心结构生物学实验室,博士后
   美国普林斯顿大学分子生物学系,助理教授
   美国普林斯顿大学分子生物学系,(终身)副教授
   美国普林斯顿大学分子生物学系,(终身)教授
   美国普林斯顿大学分子生物学系,Warner-Lambert/Parke-Davis教授
  2008-至今 清华大学生命科学学院,教授、博士生导师
  主要科研领域与方向:
  主要运用结构生物学和生物化学的手段研究肿瘤发生和细胞调亡的分子机制,集中于肿瘤抑制因子和细胞凋亡调节蛋白的结构和功能研究
  与重大疾病相关膜蛋白的结构与功能的研究
  细胞内生物大分子机器的结构与功能研究
  代表性论文(5年内)
  1.Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A.Cell. 2008; 133:154-63.
  2.Xu Y, Feng L, Jeffrey PD, Shi Y*, Morel FM*. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature. 2008; 452:56-61.(* indicates co-corresponding authors)
  3.Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y. Structure of a site-2 protease family intramembrane metalloprotease. Science. 2007; 318:1608-12.
  4.Yan N, Shi Y. Allosteric activation of a bacterial stress sensor. Cell. 2007; 131:441-3. Review.
  5.Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y. Structure of the protein phosphatase 2A holoenzyme. Cell. 2006; 127:1239-51.
  6.Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell. 2006; 127:341-53.
  7.Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, Xue D, Shi Y. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature. 2005; 437 :831-7.
  8.Feng L, Zhou S, Gu L, Gell DA, Mackay JP, Weiss MJ, Gow AJ, Shi Y. Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 2005; 435:697-701.
  9.Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005; 434:926-33.
  10.Feng L, Gell DA, Zhou S, Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich AM, Armstrong RS, Lay PA, Gow AJ, Weiss MJ, Mackay JP, Shi Y. Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. Cell. 2004; 119:629-40.
  11.Shi Y. Caspase activation: revisiting the induced proximity model. Cell. 2004; 117: 855-8. Review. 
  联系方式:
  电话:+86-10-(实验室)  
  传真:+86-10-
  E-mail:shi-lab@mail.
  隋森芳 博士 教授 博士生导师
  教育工作经历
  1970, 清华大学, 学士
  1980, 清华大学, 硕士
  1988, 德国慕尼黑技术大学(Technical University Munich), 自然科学博士
  1989年至今任清华大学生命科学学院副教授、教授(1991-)、博士生导师。
  主要研究领域与方向
  主要利用冷冻电子显微学及三维重构技术,并结合生物化学和生物物理学等技术手段研究蛋白质复合体及复杂蛋白质机器的结构与功能, 研究膜蛋白的结构与功能。
  把分子生物学,细胞生物学及结构生物学等多学科技术手段结合起来研究囊泡运输中的分子机制, 蛋白质与膜脂的相互作用,生物膜与重大疾病的关系。
  代表性论文
  1.Q-T Shen, X-C Bai, L-F Chang, Yi Wu, Hong-Wei Wang, Sen-Fang Sui* (2009) Bowl-Shaped Oligomeric Structures on Membranes as DegP's new functional forms in Protein Quality Control. Proc. Natl. Acad. Sci. USA, 106(2009), .
  2.Fan Zhang, Shan Sun, Du Feng, Wen-Long Zhao, Sen-Fang Sui* (2009) A novel Strategy for the Invasive Toxin: Hijacking Exosome-mediated Intercellular Trafficking. Traffic 10 (2009) 411-424.
  3.Jiansen Jiang, X. Zhang, Y. Chen, Y. Wu, Z. H. Zhou, Zengyi Chang*, Sen-Fang Sui* (2008) Activation of DegP Chaperone-Protease via Formation of Large Cage-like Oligomers Upon Binding to Substrate Proteins. P. Natl. Acad. Sci. USA, 105(2008) .
  4.Shan Sun, Feng Chen, Tong-Jin Zhao, Xiao-Hong Fang, Yi-Qoin Li, Sen-Fang Sui* (2008) TINY, a DREB-like Transcription Factor Connecting the DRE- and ERE-mediated Signaling Pathways in Arabidopsis. J. Biological Chemistry 283(-6271.
  5.Y Chen, X Pan, Y Tang, S Quan, P Tai, Sen-Fang Sui* (2008) Full length E.coli SecA dimerizes in a closed conformation in solution as determined by cryo- electron microscopy. J. Biological Chemistry 283(2008) .
  6.Shi-Zhen Wang, Yong Chen, Zhan-Hua Sun, Qiang Zhou, Sen-Fang Sui* (2006) Escherichia coli CorA periplasmic domain function as homotetramer to bind substrate. J. Biological Chemistry, 281(2006) . 
  7.H.W.Wang, Y.Chen, H.Yang, X.Chen, M.X.Duan, P.C.Tai*, Sen-Fang Sui* (2003) Ring-like pore structures of SecA: Implication for bacterial protein-conducting channels. P. Natl. Acad. Sci. USA, 100(-4226.
  8.Yi Wu, Y.H. He, J.Bai, S.R.Ji, W.C,Tucker, E.R.Chapman*, Sen-Fang Sui* (2003) Visualization of synaptotagmin I oligomers assembled onto lipid monolayers. P. Natl. Acad. Sci. USA, 100(-2087.
  9.Shang-Rong Ji, Yi Wu and Sen-fang Sui* (2002) Cholesterol is an important factor affecting the membrane insertion of b-amyloid peptide (Ab1-40),which may potionally inhibit the fibril formation. J. Biological Chemistry 277(-6279.
  10.Zhanfang Ma and Sen-fang Sui* (2002) Naked-Eye Sensitive Detection of Immunoglubulin G by Enlargement of Au-Nanoparticles in Vitro. Angewandte Chemie International Edition 41(-2179.
  2000年获中国高校科技进步奖(自然科学奖)一等奖。
  2001年获全国优秀博士学位论文博士生导师。
  2004年《膜分子生物学》获北京市高等教育精品教材奖。
  2005年获国家自然科学奖二等奖。
  2006年获&北京市教育创新标兵&称号。
  联系方式:
  电话:+86-10-72214
  传真:+86-10-
  E-mail:suisf@mail.
  Web: http://suilab.biosci.
  陶庆华 博士 教授,博士生导师
  教育工作经历
  1992  四川大学生物工程系遗传学专业学士
  2000  中科院上海细胞所发育生物学专业博士
   美国俄亥俄州辛辛那提市儿童医院发育生物学系博士后
  2008&至今 清华大学生命科学学院 教授
  主要研究领域和方向
  综合运用现代分子生物学,系统生物学和实验胚胎学手段,以非洲爪蟾(Xenopus)和胚胎干细胞为主要模式生物,探索脊椎动物早期胚胎发育中的基本生物学现象及生殖相关疾病发生的分子机理。主要研究兴趣和方向包括:
  1.WNT信号通路在胚胎早期发育和胚胎干细胞分化中的功能及其调控
  2.细胞粘连分子(cadherins) 在胚胎形态建成及细胞迁移中的功能
  3.胚胎多潜能前体细胞分化中的表观遗传控制机理
  4. 卵母细胞成熟的控制机理和母性基因在脊椎动物早期胚胎发育中的功能研究
  代表性论文
  1.Tao QH, Nandadasa S, McCrea P, Heasman J and Wylie C. (2007) G protein-coupled signals control actin assembly by controlling cadherin expression in the early Xenopus embryos. Development, 134(14):2651-61.
  2.Tao QH, Yokota C, Puck H, Kofron M, Birsoy B, Dong Y, Asashima M, Wylie C, Lin X and Heasman J. (2005a). Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857-871.
  3.Tao QH, Lloyd B, Lang S, Houston D, Zorn A, and Wylie C. (2005b). A novel G protein coupled receptor, related to GPR4, is required for assembly of the cortical actin in early Xenopus embryos. Development. 132:. 
  4.Lloyd B, Tao QH, Lang S and Wylie C (2005). Lysophosphatidic acid signaling controls actin assembly and cytoarchiteture in Xenopus embryos. Development. 132:805-816. 
  5.Liao GH, Tao QH, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsien JC, Wylie C, Heasman J and Kuan CY. (2006) JNK prevents nuclear b catenin accumulation and regulates axis formation in Xenopus embryos. P.N.A.S., 103(44): 16313-8.
  6.Kofron M., Birsoy B., Houston D., Tao QH, Wylie C. and Heasman J. (2007). Wnt11/beta-catenin signaling in both oocytes and early embryos acts thorugh LRP6-mediated regulation of axin. Developoment, 134(3): 503-13.
  7.Cha SW, Tadjuidje E, Tao QH, Wylie C, Heasman J(2008). Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. Development. 2008 Nov;135(22):3719-29.
  8.Sundaram N, Tao QH, Wylie C and Heasman J. (2003). The role of maternal CREB in early embryogenesis of Xenopus laevis. Dev Biol. 261(2):337-52.
  9.Xanthos JB, Kofron M, Tao QH, Schaible K, Wylie C, Heasman J. (2002). The roles of three signaling pathways in the formation and function of the Spemann Organizer. Development. 129(17):4027-43. 
  联系方式:
  电话:
  E-mail: qhtaolab@mail.
  王志新教授、院士,博士生导师
  教育工作经历
  :清华大学化学与化学工程系,学生
  :中国科学院生物物理研究所,研究生(1988年获理学博士学位)
  : 清华大学化学与化学工程系,助教
  : 中国科学院生物物理研究所,副研究员
  : 美国康乃尔大学化学系,博士后
  : 美国北达哥他州立大学生物化学系,研究助理
  : 中国科学院生物物理研究所,研究员
  : 中国科学院生物物理研究所,副所长
  : 中国科学院生物物理研究所,所长
  : 北京生物大分子国家重点实验室,主任
  2003 -至今   清华大学生命科学学院,教授
  研究方向:分子酶学和生物信息学
  代表性论文:
  1.Zhang, Y.Y., Mei, Z.Q., Wu, J.W. and Wang, Z.X. (2008) Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states. J. Biol. Chem. 283(39):.
  2.Yuan, Z. and Wang, Z.X. (2008) Quantifying the relationship of protein burying depth and sequence. Proteins 70, 509-16.
  3.Wang, Z.X. and Wu, J.W. (2007) The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism. J. Biol. Chem. 282(38): 27678-84.
  4.Liu J.H. and Wang, Z.X. (2004) Kinetic analysis of ligand-induced autocatalytic reactions. Biochem. J.379, 697-702.
  5.Wu, H. and Wang, Z.X. (2003) The mechanism of p21-activated protein kinase 2 autoactivation. J. Biol. Chem. 278, .
  6.Wang, Z.X. and Wu, J.W. (2002) Autophosphorylation kinetics of protein kinases. Biochem. J. 368, 947-952.
  7.Wang, Z.X. and Yuan, Z. (2000) How good is the prediction of protein structural classes by the component-coupled method? Proteins 38, 165-175.
  8.Wang, Z.X. (1999) Influence of substrates on in vitro dephosphorylation of glycogen phosphorylase a by protein phosphatase-1. Biochem. J. 341, 545-554.
  9.Wang, Z.X. (1996) How many fold types of protein are there in nature? Proteins 26, 186-191.
  10.Wang, Z.X. (1994) Assessing the accuracy of protein secondary structure. Nat. Struct. Biol. 1, 145-146.
  学术荣誉:
  1990年获中国科学院自然科学奖一等奖
  1993年获国家自然科学奖二等奖
  1993年获中国科学院青年科学家奖一等奖
  1994年获中国青年科学家奖
  1997年当选中国科学院院士
  1999年当选第三世界科学院院士
  主要学术兼职:
  中国生物化学与分子生物学学会,理事长(2005-)
  中国生物物理学学会,副理事长()
  美国生物化学与分子生物学学会,会员
  联系方式:
  电话:010-
  传真:010-
  电子邮箱:zhixinwang@mail.
  通讯地址:清华大学生命科学学院,北京 100084
  王新泉 博士 教授  博士生导师
  教育工作经历
  ,复旦大学 学士
  ,中国科学院生物物理研究所 博士
  ,中国科学院生物物理研究所 助理研究员
  ,美国斯坦福大学 博士后
   2008年至今,清华大学教授
  主要科研领域和方向:细胞表面配基/受体复合物的结构生物学和生物化学研究
  代表性论文
  1.Wang XQ, Lupardus P, LaPorte SL and Garcia KC. Structural biology of shared cytokine receptors. Annu. Rev. Immunol. 27, 29-60 (2009).
  2.Wang XQ, Baloh RH, Milbrandt J and Garcia KC. Structure of Artemin with its receptor GFRa3: convergent recognition of glial-cell line derived neurotrophic factors. Structure 14,
  3.Wang XQ*, Rickert M* and Garcia KC. Structure of the quaternary complex of interleukin-2 with of its a, b, and gc receptors. Science 310,
(2005). *equal authorship.
  4.Rickert M*, Wang XQ*, Boulanger MJ, Goriatcheva N and Garcia KC. The structure of Interleukin-2 complexed with its alpha receptor. Science 308,
(2005). *equal authorship.
  5.Wang XQ, He XY, Yang SJ, An XM, Chang WR and Liang DC. Structural basis for the thermostability of b-glycosidase from the thermophilic eubacterium Thermus nonproteolytics HG102. J. Bacteriol. 185,
  6.Wang XQ, Li LN, Chang WR, Zhang JP, Gui LL, Guo, BJ and Liang DC. Structure of C-phycocyanin from Spirulina platensis at 2.2A resolution: a novel monoclinic crystal form for phycobiliproteins in phycobilisomes. Acta Cryst. D57, 784-792 (2001).
  联系方式:
  电话:+86-10-
  传真:+86-10-
  E-mail: xinquanwang@mail.
  吴嘉炜教授、博士生导师
  教育工作经历:
  ,南京大学基础学科教育强化部,获生物化学学士学位
  ,中国科学院生物物理研究所,获分子生物学博士学位
  ,普林斯顿大学分子生物学系,博士后,研究助理
  2003-   清华大学生命科学学院,教授
  研究方向:
  生物大分子的结构生物化学研究:
  糖尿病、肥胖症等疾病中关键蛋白的结构和功能研究
  Wnt信号转导中骨架蛋白Axin及其相互作用蛋白的研究
  MAPK信号通路中激酶和磷酸酶活力调控的分子机制
  TGF-b信号通路中Smad蛋白的泛素化降解机制
  代表性论文:
  1.Chen L, Jiao ZH, Zheng LS, Zhang YY, Xie ST, Wang ZX, Wu JW*. (2009) Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature. [Epub ahead of print]
  2.Zhang YY, Mei ZQ, Wu JW*, Wang ZX*. (2008) Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states. J Biol Chem. 283(39):.
  3.Wang ZX*, Wu JW.* (2007) The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism. J Biol Chem. 282(38): 27678-84.
  4.Yan N, Wu JW, Chai J, Li W, Shi Y. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol. 11(5):420-8.
  5.Chai J, Wu JW, Yan N, Massague J, Pavletich NP, Shi Y. (2003) Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J Biol Chem. 278(22):20327-31.
  6.Wu WJ, Krawitz AR, Chai J, Li W, Luo K, Shi Y. (2002) Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell. 111(3): 357-367.
  7.Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massague J, Shi Y. (2001) Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and on Smad function in TGF-beta signaling. Mol Cell. 8(6),1277-89. (Cover story)
  8.Wu JW, Cocina AE, Chai J, Hay BA, Shi Y. (2001) Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol Cell. 8(1), 95-104.
  9.Wu JW, Wang ZX. (1999) New Evidence for the Denaturant Binding Model, Protein Sci. 8(10), .
  10.Wu JW, Wang ZX. (1998) Activation Mechanism and Modification Kinetics of Chinese Hamster Dihydrofolate Reductase by p-Chloromercuribenzoate, Biochem. J. 335(1), 181-189.
  学术荣誉:
  1997年,中国科学院院长奖优秀奖
  1998年,中国科学院地奥奖
  1999年,中国科学院院长奖特别奖
  2001年,全国百篇优秀博士学位论文
  主要学术兼职:
  中国生物化学与分子生物学学会,会员
  中国生物化学与分子生物学学会酶学专业委员会,委员(2007-)
  中国晶体学会,会员
  联系方式:
  电话:010-
  传真:010-
  电子邮箱:jiaweiwu@mail.
  通讯地址:清华大学生命科学学院,北京 100084
  吴庆余 教授,博士生导师,国家杰出青年基金获得者,首届国家教学名师奖获得者
  教育工作经历
  1982年,南京大学学士
  1985年,南京大学硕士
  1988年-1990年,美国William Paterson University of New Jersey 访问学者
  1993年-1994年,美国Arizona State University访问学者
  现任清华大学教授、生物学学位分委员会主席、生物技术研究所所长
  主要科研领域与方向:微藻生物能源、蓝细菌分子生物学、微生物地球化学
  代表性论文
  1.Xiaoling Miao, Qingyu Wu, 2006, Biodiesel production from heterotrophic microalgal oil. Bioresource Technology, 97: 841-846.
  2.Han Xu and Qingyu Wu, 2006, High quality biodiesel production from a microalgae Chlorella protothecoides by heterotrophic growth in fermenters. Journal of Biotechnology, 126: 499-507.
  3.Xiufeng Li, Han Xu, Qing

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