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DrugBank. IdentificationNamePuromycinAccession NumberDB08437TypeSmall MoleculeGroupsExperimentalDescriptionPuromycin is an antibiotic that is a protein synthesis inhibitor by inhibiting translation. Puromycin is used in cell biology as selective agent in cell culture systems. It is toxic to prokaryotic and eukaryotic cells.StructureSynonymsNot AvailableExternal Identifiers Not AvailableApproved Prescription ProductsNot AvailableApproved Generic Prescription ProductsNot AvailableApproved Over the Counter ProductsNot AvailableUnapproved/Other Products Not AvailableInternational BrandsNot AvailableBrand mixturesNot AvailableSaltsNot AvailableCategories
UNIICAS number53-79-2WeightAverage: 471.5096 Monoisotopic: 471. Chemical FormulaC22H29N7O5InChI KeyInChIKey=RXWNCPJZOCPEPQ-NVWDDTSBSA-NInChIInChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1IUPAC Name(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamideSMILES[H][C@](N)(CC1=CC=C(OC)C=C1)C(=O)N[C@]1([H])[C@@]([H])(CO)O[C@@]([H])(N2C=NC3=C(N=CN=C23)N(C)C)[C@]1([H])OTaxonomyDescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.KingdomSuper ClassClassSub ClassDirect ParentAlternative Parents
SubstituentsAlpha-amino acid amide
6-alkylaminopurine
N-glycosyl compound
Glycosyl compound
Phenylpropylamine
Amphetamine or derivatives
6-aminopurine
Imidazopyrimidine
Methoxybenzene
Dialkylarylamine
Phenol ether
Aralkylamine
Aminopyrimidine
Alkyl aryl ether
Fatty acyl
Imidolactam
Pyrimidine
N-substituted imidazole
Monosaccharide
Fatty amide
Saccharide
Monocyclic benzene moiety
Heteroaromatic compound
Tertiary amine
Secondary carboxylic acid amide
Secondary alcohol
Carboxamide group
Organoheterocyclic compound
Carboxylic acid amide
Hydrocarbon derivative
Primary amine
Primary alcohol
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Aromatic heteropolycyclic compoundMolecular FrameworkAromatic heteropolycyclic compoundsExternal Descriptorspuromycins ()PharmacologyIndicationNot AvailablePharmacodynamicsNot AvailableMechanism of actionNot AvailableRelated ArticlesAbsorptionNot AvailableVolume of distributionNot AvailableProtein bindingNot AvailableMetabolismNot AvailableRoute of eliminationNot AvailableHalf lifeNot AvailableClearanceNot AvailableToxicityNot AvailableAffected organismsNot AvailablePathwaysNot AvailableSNP Mediated EffectsNot AvailableSNP Mediated Adverse Drug ReactionsNot AvailableADMETPredicted ADMET featuresPropertyValueProbabilityHuman Intestinal Absorption+0.9747Blood Brain Barrier-0.8691Caco-2 permeable-0.7728P-glycoprotein substrateSubstrate0.737P-glycoprotein inhibitor INon-inhibitor0.8782P-glycoprotein inhibitor IINon-inhibitor0.8382Renal organic cation transporterNon-inhibitor0.9243CYP450 2C9 substrateNon-substrate0.8029CYP450 2D6 substrateNon-substrate0.8107CYP450 3A4 substrateSubstrate0.7097CYP450 1A2 substrateNon-inhibitor0.9058CYP450 2C9 inhibitorNon-inhibitor0.9133CYP450 2D6 inhibitorNon-inhibitor0.9231CYP450 2C19 inhibitorNon-inhibitor0.9393CYP450 3A4 inhibitorNon-inhibitor0.724CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8922Ames testNon AMES toxic0.8607CarcinogenicityNon-carcinogens0.8681BiodegradationNot ready biodegradable0.9882Rat acute toxicity2.2651 LD50, mol/kg Not applicablehERG inhibition (predictor I)Weak inhibitor0.9903hERG inhibition (predictor II)Non-inhibitor0.5719 ADMET data is predicted using , a free tool for evaluating chemical ADMET properties. () PharmacoeconomicsManufacturersNot AvailablePackagersNot AvailableDosage formsNot AvailablePricesNot AvailablePatentsNot AvailablePropertiesStateSolidExperimental PropertiesSourcemelting point168°C-182°Chttp://www.fermentek.co.il/puromycin.htmwater solubility50mg/mlhttp://www.fermentek.co.il/puromycin.htmPredicted PropertiesSourceWater Solubility1.01 mg/mLlogP-0.1logP-0.3logS-2.7pKa (Strongest Acidic)12.35pKa (Strongest Basic)8.03Physiological Charge1Hydrogen Acceptor Count10Hydrogen Donor Count4Polar Surface Area160.88 ?2Rotatable Bond Count8Refractivity122.96 m3·mol-1Polarizability49.46 ?3Number of Rings4Bioavailability1Rule of FiveYesGhose FilterYesVeber's RuleYesMDDR-like RuleYesSpectraMass Spec (NIST)Not AvailableSpectraPredicted LC-MS/MSsplash10-03di--347a5da10b8c2c85e6c0Predicted LC-MS/MSsplash10-03dj--4a2ce92deaaPredicted LC-MS/MSsplash10-03dj--b89c78bd0b11Predicted LC-MS/MSsplash10-000-37dea53aac093ce884f6Predicted LC-MS/MSsplash10-03di--f60802f57acdPredicted LC-MS/MSsplash10-03xs--d2fbe55b1fReferencesSynthesis ReferenceNot AvailableGeneral ReferencesNot AvailableExternal LinksResourceLinkPubChem CompoundPubChem SubstanceChemSpiderChEBIHETATC CodesNot AvailableAHFS CodesNot AvailablePDB EntriesNot AvailableFDA labelNot AvailableMSDSNot AvailableInteractionsDrug InteractionsNot AvailableFood InteractionsNot AvailableTargets1. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:May play a role in compensating for the inactivated X-linked gene during spermatogenesis.Gene Name:RPL10LUniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 2. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribo...Gene Name:RPL13AUniprot ID:Molecular Weight:23577.11 DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 3. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Not AvailableGene Name:RPL23Uniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 4. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Not AvailableGene Name:RPL15Uniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 5. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Not AvailableGene Name:RPL19Uniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 6. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:This protein binds to a specific region on the 26S rRNA.Gene Name:RPL23AUniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 7. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).Gene Name:RSL24D1Uniprot ID:Molecular Weight:19621.02 DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 8. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Not AvailableGene Name:RPL26L1Uniprot ID:Molecular Weight:17256.2 DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 9. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Not AvailableGene Name:RPL8Uniprot ID:Molecular Weight:28024.52 DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 10. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Binds to the 23S rRNA.Gene Name:RPL37Uniprot ID:Molecular Weight:11077.81 DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 11. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:The L3 protein is a component of the large subunit of cytoplasmic ribosomes.Gene Name:RPL3Uniprot ID:Molecular Weight:46108.72 DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 12. KindProteinOrganismHumanPharmacological actionunknownGeneral Function:Structural constituent of ribosomeSpecific Function:Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).Gene Name:RPL11Uniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [] 13. KindProteinOrganismEscherichia coli (strain K12)Pharmacological actionunknownGeneral Function:Transferase activity, transferring amino-acyl groupsSpecific Function:Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.Gene Name:aatUniprot ID:Molecular Weight: DaReferencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. []
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Drug created on September 15,
/ Updated on August 17,& 细胞培养嘌呤霉素Puromycin价格P8833厂家现货
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细胞培养嘌呤霉素Puromycin价格P8833厂家现货
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有效期至：长期有效
细胞培养嘌呤霉素Puromycin价格P8833厂家现货&&本信息的网址是：/tradeinfo/chanpin_detail_6417915.html细胞培养嘌呤霉素Puromycin价格P8833厂家现货58-58-2
Biotech Grade
产品规格 您的价格
25mg 650.00 P7255
特殊规格 请询价
说明：嘌呤霉素是一种由链霉菌中获取的氨基核苷抗生素，它能抑制真核和原核生物的核糖体上发生的肽基转移。该抗生素可以作用于革兰氏阳性菌和各种动物、昆虫细胞。真菌和革兰氏阴性菌对其不敏感源于对该抗生素的渗透率较低。但是在一些特别的条件下，嘌呤霉素可作用于大肠杆菌。30多年来，嘌呤霉素作为研究蛋白合成的基本工具被广泛使用。如今，嘌呤霉素盐酸盐更可以用来挑选有该抗生素抑制基因的质粒。嘌呤霉素是一种蛋白质合成抑制剂,它具有与tRNA分子末端类似的结构, 能够同氨基酸结合，代替氨酰化的tRNA同核糖体的A位点结合，并掺入到生长的肽链中。虽然嘌呤霉素能够同A位点结合,但是不能参与随后的任何反应, 因而导致蛋白质合成的终止并释放出C-末端含有嘌呤霉素的不成熟的多肽。
细胞培养嘌呤霉素Puromycin价格P8833厂家现货58-58-2英文名：Puromycin, dihydrochloride (Stylomycin, P638) from Streptomyces alboniger 包装：25mg 类别：生化试剂类
CAS:58-58-2
中文名：嘌呤霉素盐酸盐
分子式：C22H31N7O5Cl2
分子量 544.43
Purity &98%
总铁结合力(TIBC)检测试剂盒(亚铁嗪微板法) 100T
总铁结合力(TIBC)检测试剂盒(亚铁嗪比色法) 50T
铁检测试剂盒(亚铁嗪微板法) 100T
铁检测试剂盒(亚铁嗪比色法) 50T
钙检测试剂盒(甲基麝香草酚蓝微板法) 100T
钙检测试剂盒(甲基麝香草酚蓝比色法) 50T
钙检测试剂盒(邻甲酚酞络合铜微板法) 100T
钙检测试剂盒(邻甲酚酞络合铜比色法) 50T
无机磷检测试剂盒(黄嘌呤氧化酶比色法) 50T
总胆红素(TBIL)检测试剂盒(改良Jendrassik-Grof微板法) 100T
细胞培养嘌呤霉素Puromycin价格P8833厂家现货58-58-2总胆红素(TBIL)检测试剂盒(改良Jendrassik-Grof比色法) 50T
无机磷检测试剂盒(紫外分光光度微板法) 100T
无机磷检测试剂盒(紫外分光光度比色法) 100T
无机磷检测试剂盒(硫酸亚铁钼蓝微板法) 100T
无机磷检测试剂盒(硫酸亚铁钼蓝比色法) 50T
无机磷检测试剂盒(硫酸亚铁钼蓝比色法) 100T
无机磷检测试剂盒(米吐尔钼蓝微板法) 100T
无机磷检测试剂盒(米吐尔钼蓝比色法) 100T
镁检测试剂盒(甲基麝香草酚蓝微板法) 100T
镁检测试剂盒(甲基麝香草酚蓝比色法) 50T
镁检测试剂盒(甲基麝香草酚蓝比色法) 100T
镁检测试剂盒(Calmagite微板法) 100T
镁检测试剂盒(Calmagite比色法) 100T
铜检测试剂盒(Cuprizone微板法) 100T
铜检测试剂盒(Cuprizone比色法) 50T
锌检测试剂盒(吡啶偶氮酚微板法) 120T
锌检测试剂盒(吡啶偶氮酚比色法) 60T
锌检测试剂盒(吡啶偶氮酚比色法) 120T
总胆红素(TBIL)检测试剂盒(改良Jendrassik-Grof比色法) 100T
总胆红素(TBIL)检测试剂盒(钒酸微板法) 100T
总胆红素(TBIL)检测试剂盒(钒酸比色法) 50T
总胆红素(TBIL)检测试剂盒(钒酸比色法) 100T
总胆红素(TBIL)检测试剂盒(BOD微板法) 100T
总胆红素(TBIL)检测试剂盒(BOD比色法) 50T
直接胆红素(DBIL)检测试剂盒(改良Jendrassik-Grof微板法) 100T
细胞培养嘌呤霉素Puromycin价格P8833厂家现货58-58-2直接胆红素(DBIL)检测试剂盒(改良Jendrassik-Grof比色法) 50T
直接胆红素(DBIL)检测试剂盒(改良Jendrassik-Grof比色法) 100T
直接胆红素(DBIL)检测试剂盒(钒酸微板法) 100T
直接胆红素(DBIL)检测试剂盒(钒酸比色法) 50T
直接胆红素(DBIL)检测试剂盒(钒酸比色法) 100T
直接胆红素(TBIL)检测试剂盒(BOD微板法) 100T
直接胆红素(TBIL)检测试剂盒(BOD比色法) 50T
总胆汁酸(TBA)检测试剂盒(酶微板法) 100T
总胆汁酸(TBA)检测试剂盒(酶比色法) 50T
血浆氨(NH3)检测试剂盒(GDH比色法) 50T
尿素(Urea)检测试剂盒(酶偶联速率法) 50Tmp: 168℃-178℃
吸收波长:275 nm & 267nm
性状：. 溶于水(50mg/ml)银杏提取物,白色或类白色粉末。
保存：-20℃
From SigmaP
细胞培养嘌呤霉素Puromycin价格P8833厂家现货58-58-2
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