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　　市场上出现注射或服用男性荷尔蒙以增强男性雄风的广告，医生认为此法不可行，反而可能成为前列腺病症高危险群，如果罹患前列腺癌再企图以男性荷尔蒙改善性机能，也会加重病情。 　　前列腺癌症状与前列腺肥大几乎相同，约百分之二前列腺肥大会恶化为癌症；五十岁以上男性较易罹患前列腺癌，初期症状不明显，但肿瘤愈来愈大，就压迫周围器官，引发排尿困难、频尿、夜尿、残尿感、血尿等，严重时会移转淋巴结、骨头，但只要早期发现，早期治疗，存活率高出其它癌症很多。 　　男性荷尔蒙分泌不足，会影响性器官发育及生理功能，最好向医疗院所求诊，适量男性荷尔蒙治疗后即可获得改善，如果自行服用或注射过量男性荷尔蒙，尤其是年长民众，将成为前列腺癌症的高危险群。一旦罹患前列腺癌，如果再摄取男性荷尔蒙，病情将加剧。 　　前列腺病患采手术切除、放射线治疗，晚期患者则使用荷尔蒙治疗或睾丸切除术治疗。 （编辑：张艳）
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Methods Analyzed the indication of 855 cases with emergency CS who were admitted in Peking University First Hospital from Jan.2002 to Dec.2003 retrospectively.
方法回顾性分析北京大学第一医院妇产科2002年1月至2003年12月两年间855例急诊剖宫产的手术指征。
Application of continuous quality improvement (CQI) in clinical work——Analysisof quality management in the center of peritoneal dialysis in Peking University First Hospital
持续性质量改进(CQI)在临床工作中的应用——北京大学第一医院腹膜透析中心质量管理经验分析
Methods To analyse the clinical and pathological data of IgAN patients of Peking University First Hospital during the recent 15 years,and the clinical,pathological and renal survival rate of EPIgAN were compared with that of non-EPIgAN.
方法分析北京大学第一医院近15年来IgA肾病(IgAN)的临床和病理资料,比较EPIgAN与非EPIgAN临床病理特点和肾脏存活率;
Methods A prospective case-control study was performed in 85 women with GDM, 63 cases with GIGT and 125 cases as control recruited from Feb 2004 to Aug 2004 in Peking University First Hospital. Univariate analysis and multivariate logistic regression were used to identify risk factors of GDM and GIGT.
方法采用前瞻性对照研究的方法,对2004年2月至8月,在北京大学第一医院妇产科门诊行产前检查诊断的糖代谢异常孕妇[其中GDM85例(GDM组)、GIGT63例(GIGT组)]和125例糖代谢正常孕妇(对照组)的临床资料进行单因素及多因素logistic回归分析,探讨各因素对GDM和GIGT发病的影响。
Methods:1119 women who delivered at Peking University First Hospital from Jan 1,2005 to June 20,2005 were recruited,to determine the prevalence of VVC during pregnancy and antepartum,and in women with abnormal glucose metabolism.
方法:回顾性调查日至日在北京大学第一医院分娩的1119例孕妇孕前及孕期VVC的发病情况。
METHODS:The experiment was finished in the Department of Neurology,First Hospital of Peking University between September 2002 and July 2004.The contents of plasma TXB2,6
PGF1αand TXB2/6
PGF1αwere measured in 313 middle
aged and 764 elderly patients with accte cerebral infarction and in 80 health persons(control group).
方法:4-07在北京大学第一医院神经科采用ELISA法测定了313例中年人和764例老年人急性脑梗死者血浆TXB2,6-keto-PGF1α及TXB2/6-keto-PGF1α的水平并与80例健康人对照。
METHODS: The experiment was performed in the Animal Experimental Center, First Affiliated Hospital of Peking University and Laboratory of Department of Neurology, Beijing Jishuitan Hospital from January 2003 to November 2003. Totally 24 male Wistar rats were randomly divided into 3 groups with 8 rats in each group :① Isoproterenol-treated group (ISO group) :The rats were injected subcutaneously with isoproterenol 5 mg/kg per day for successive 7 days for preparing chronic myocar
方法:实验于在北京大学第一医院动物实验中心和北京市积水潭医院神经内科实验室进行。 取雄性Wistar大鼠24只随机分为3组,每组8只:①异丙肾上腺素组:皮下注射异丙肾上腺素5mg/(kg·d),制成慢性心肌缺血模型,连续7d;
Methods By the retrospective study,the data of 201 IBD patients was analysed.
方法对3-12期间北京大学第一医院收治的201例IBD患者的临床资料进行回顾性分析。
Methods In Sep. students from Beijing Jingshan School between 5 and 19 years of age were investigated by the Department of Pediatrics of the First Hospital of Peking University,and enzymology was used to measure serum TC,TG,HDL-C and LDL-C.
方法北京大学第一医院儿科等于2004年9月,调查并分析了962名北京市景山学校在校学生(5~19岁)的血脂浓度,其中采用酶法测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)等4项指标。
Methods Ten hospitalized patients with operation and pathological diagnosis of insulinoma during the period from Oct.2000 to Apr.2006 were retrospectively analyzed.
方法回顾性分析2000年10月至2006年4月北京大学第一医院住院手术且术后病理诊断的胰岛素瘤10例临床资料。
Peking University Shougang Hospital
北京大学首钢医院
MethodsHuman normal corneal specimens were obtained from eye bank of the first teaching hospital of Peking university.
方法标本来源于北京大学第一医院眼库。
THE FIRST HOSPITAL OF XIAMEN
厦门市第一医院
THE FIRST HOSPITAL OF QINHUANGDAO
秦皇岛市第一医院
The surgical ward building of the second in-patient department of the Peking University First Hospital for officials
北京大学第一医院第二住院部干部外科病房楼
查询“北京大学第一医院”译词为用户自定义的双语例句&&&&我想查看译文中含有：的双语例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。&&&&&&&& Objective: To evaluate the changes of
blood glucose in newborns of abnormal glucose metabolic pregnant women with ideal treatment of blood glucose. Methods: 90 cases
were chosen from
April 1998 to November 1999, including 30 newborns with ideal treatment of blood glucose in abnormal glucose metabolic pregnant women and 60 newborns of normal glucose metabolic pregnant women, in which 26 cases were larger
for gestational age(LGA) and
34 cases(control group) were normal birth weight infants. Blood glucose... &&&&&&&&&&&&目的 :探讨妊娠期糖代谢异常孕妇孕期血糖控制满意后 ,新生儿早期动态血糖变化。方法 :选择 1998年4月至 1999年 11月北京大学第一医院糖代谢异常孕妇孕期血糖控制满意者所分娩的新生儿 30例 ;糖代谢正常孕妇所分娩的新生儿 6 0例 ,其中大于胎龄儿 2 6例 ,正常体重儿 (对照组 ) 34例。新生儿出生后分别于第 2、4、8、2 4小时测定微量血糖 ,并监测血色素、红细胞压积、微量胆红素及体温等。结果 :糖代谢异常孕妇血糖控制满意组新生儿出生 2、4、8、2 4h微量血糖值 [(3 .3± 0
5 ) ,(3 .4± 0 .4) ,(3 .6± 0 .5 ) ,(3 .6± 0 .6 )mmol·L-1, x±s]与对照组[(3 .2± 0 .4) ,(3.3± 0 .4) ,(3 .3± 0 .4) ,(3.4± 0 .3)mmol·L-1, x±s]相比 ,差异无显著性 (P >0 .0 5 ) ,无低血糖发生 ;且新生儿出生体重也与对照组相近。结论 :严格控制糖代谢异常孕妇孕期血糖 ,可使新生儿出生早期血糖与糖代谢正常母亲的新生儿相近 ,且降低新生儿早期低血糖的发生&&&&&&&& Objective To evaluate the efficacy and toxicity of Fluorouracil and Cisplatin - Vincristine - Pingyangmycin (VPB) for the treatment of malignant gestational trophoblastic tumor.Methods 43 cases of malignant gestational trophoblastic tumor admitted between 1991 to 2001 in our hospital were retrospectively studied. Statistical package for social sciences (SPSS) was used comparing the differences in efficacy and toxicity between two different regimens.Results 28 patients had invasive mole, 21 cases (75%) were ... &&&&&&&&&&&&目的 评价5-FU与VPB方案治疗恶性滋养细胞肿瘤的疗效及副反应。方法 回顾性分析北京大学第一医院自1991年至2001年收治的43例恶性滋养细胞肿瘤的疗效、副反应。结果28例侵袭性葡萄胎中26例(92.9％)及15例绒癌中12例(80％)临床治愈。我院39例恶性滋养叶细胞肿瘤治疗中采用5-FU方案和VPB方案,有效率均可达91.3％,但其中5-FU方案化疗副反应发生率较VPB方案高,其中主要包括严重消化道反应、发热与感染、严重骨髓抑制,且5-FU方案每疗程住院天数较VPB方案天数长(P<0.05)。结论5-FU方案和VPB方案有效率差异无显著性,5-FU方案化疗副反应发生率较VPB方案高,住院时间长,但较VPB方案价廉。&&&&&&&& Purpose:Observe the value of diagnosing the coronary heart disease of work amount machine of treadmill of Model EGM-Ⅲ that the medical instrument and equipment factory,the first hospital of Beijing Univetsity of yueyang jointly develop.Modle:Adopt the movement esperiment FOX scheme of treadmill.Result:Observe 248,dropand rise and greater than or equal 1mv by section with ST,sport appear angina pectoris,rhythm of the heart the positive standard.Obserne T wave it changes to be can as positivereference standar... &&&&&&&&&&&&目的 :观察岳阳医疗仪器设备厂、北京大学第一医院联合研制的EGM -Ⅲ型踏车功量机诊断冠心病的价值。方法 :采取踏车运动试验FOX方案。结果 :观察 2 4 8例 ,以ST段下降与升高大于或等于 1mV ,运动中出现了心绞痛、心率失常为阳性标准。观察T波改变可作为阳性病人的参考标准 ,R波下降不可作为阳性病人的参考标准 ,血压高低不可作为阳性病人的诊断标准 ,心率仅可作为终止试验标准&nbsp&&&&&&&&相关查询:
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2008 CNKI－中国知网
北京市公安局海淀分局 备案号：110 1081725
&2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社可注射硫酸钙MIIGX3与医用骨水泥对椎弓根钉固定作用的比较研究
北京大学附属第一医院&作者：　&
文章号：W<font color=#6625&&
10:22:58&&
文字大小：
［目的］用可注射硫酸钙MIIGX3(minimally invasive injectable graft X3，以下简称MIIGX3)及医用骨水泥分别强化猪腰椎椎弓根钉内固定，测定椎弓根钉最大轴向拔出力，比较两种材料对椎弓根钉固定强度的影响。［方法］8个新鲜猪腰椎作为实验对象，在同一椎体双侧椎弓根制作钉道，一侧在固定螺钉前加用MIIGX3(MIIGX3组)，另一侧加用骨水泥(骨水泥组)。24 h后行轴向拔出力测试。［结果］最大轴向拔出力，MIIGX3组 N，骨水泥组 N，二者配对t检验有显著差异(P<001）。［结论］骨水泥对椎弓根钉的固定作用大于MIIGX3。当存在脊柱滑脱需较大提拉力量或椎弓根钉需承受较大拔出力的节段，使用骨水泥进行强化更为合适。
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2014年度全国医院影响力分析 综合第九名：北京大学第一医院
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北京大学第一医院不断完善科室建设，泌尿外科、儿科、皮肤科、肾脏内科、妇产科、心血管内科、内分泌科、传染科均为全国领先水平，中医、中西医结合科、血液内科、骨科、眼科、病理科、核医学科均为全国一流科室。领先水平科室提高其排名权重，特别推荐泌尿外科、儿科、皮肤科、肾脏内科、妇产科、心血管内科、内分泌科、传染科患者选择北京大学第一医院就诊。
北京大学第一医院论文（国内）
彭超周应芳廖秦平子宫腺肌病患者痛经强度与前列腺素的相关性研究实用妇产科杂志
摘要：目的检测子宫腺肌病患者血浆、腹水与组织匀浆中前列腺素、和α的含量分析其与患者痛经强度的相关性。方法研究组子宫腺肌病组例对照组子宫肌瘤组例研究组患者术前均对痛经强度进行评分采用放免法测定血浆、腹水与腺肌病病灶、子宫肌层组织匀浆中前列腺素、和α的含量。结果腺肌病组患者血浆水平显著高于对照组且与痛经强度评分呈正相关。腺肌病患者月经期血浆前列腺素、和α与手术期比较差异无显著性。腺肌病组患者腹水中前列腺素、和α水平与对照组相比差异无显著性且与痛经强度评分无相关性。腺肌灶组织匀浆含量显著高于腺肌病正常肌层和子宫肌瘤正常肌层腺肌灶、和α含量均与痛经强度评分呈正相关。结论腺肌病病灶局部合成异常增多是导致痛经的重要原因之一。
毕蕙廉玉茹李克敏ⅡⅢ治疗后随访情况分析实用妇产科杂志
摘要：目的探讨宫颈上皮内瘤样病变ⅡⅢ患者高频电波刀宫颈电圈环切术治疗的有效性。方法对ⅡⅢ行手术的例患者进行为期年的随访对手术后患者的病灶持续存在和复发等情况进行分析总结。结果个月总的治愈率为病变持续存在率术后年复发率为年时复发率为年、年、年无复发。其中Ⅱ例月治愈率病变持续存在率年复发率为年复发率为Ⅲ例月治愈率为病变持续存在率年复发率Ⅱ、Ⅲ在治愈率、病变持续存在率、复发率方面比较差异无显著性。结论对于ⅡⅢ患者的治疗是安全、有效的但需长期随访尤其是术后前年。
杨慧霞妊娠合并糖尿病的诊治进展中国实用妇科与产科杂志
汪涛腹膜透析的现状和展望中国实用内科杂志
张玉立杨慧霞妊娠期糖尿病的医学营养治疗实用妇产科杂志
李双玲王东信吴新民蒋洪外科重症监护病房医院感染和相关死亡危险因素中华医院感染学杂志
摘要：目的分析我院外科重症监护病房医院感染情况和相关死亡危险因素。方法对在年月年月收治的患者中医院感染发生、感染部位、感染病原微生物等进行回顾性分析并用回归分析筛选出医院感染患者死亡的相关危险因素。结果医院感染的发生率为死亡率为最常见的感染部位依次为下呼吸道、血液系统和泌尿系统病原微生物中革兰阴性杆菌占最常见的依次为铜绿假单胞菌、嗜麦芽寡养单胞菌、乙酸钙鲍氏不动杆菌和产酸克雷伯菌革兰阳性球菌占最常见的依次为耐甲氧西林金黄色葡萄球菌、耐甲氧西林表皮葡萄球菌和屎肠球菌真菌占以白色念珠菌为最常见。结论应加强对患者下呼吸道、血液系统和泌尿系统的感染监测医院感染病原菌菌种多样性和多重耐药的特点使得早期经验性抗菌药物治疗十分困难应根据医院感染病原菌的分布和药敏情况选择适当的抗菌药物。
李六亿陈菁医疗器械的清洗与去污中华医院感染学杂志
梁雁鲁云兰例中药注射剂不良反应分析中国药物警戒
摘要：目的分析中药注射剂不良反应发生的特点及规律。方法对我院～年期间中药注射剂所致不良反应报告表进行评价和分析。结果份药品不良反应报告表涉及种中药注射剂其中居前三位的是刺五加注射液、血栓通注射液和葛根素注射液。不良反应的临床表现以皮肤及其附件损害最多其次为全身性损害及消化系统损害。结论通过对中药注射剂不良反应的分析提醒临床医务人员重视中药注射剂的不良反应提高合理用药水平。
廖秦平女性阴道微生态及阴道微生态评价实用妇产科杂志
李六亿内镜医院感染现状、存在问题与管理对策中华医院感染学杂志
摘要：目的　探讨控制内镜医院感染的对策。方法　通过调查分析内镜医院感染管理的现状与存在问题。结果内镜的清洗、消毒现状不容乐观存在导致患者发生医院感染的隐患。结论　严格遵守卫生部颁布的《内镜清洗消毒技术操作规范年版》加强内镜的医院感染管理十分重要。
北京大学第一医院论文（国际）
1: Cui, Y Song, Y Wang, J Yu,Z Schuster, A Barrett, Yu C Frost, CharlesSingle- andmultiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban inhealthy Chinese subjects.Clinical pharmacology : advances and applications-84
Peking University First Hospital,Beijing, People’s Republic of China. Bristol-Myers Squibb, Princeton, NJ, USA.
BACKGROUND: The pharmacokinetics (PK),pharmacodynamics (PD), and safety of apixaban were assessed in healthy Chinesesubjects in this randomized, placebo-controlled, double-blind, single-sequence,single- and multiple-dose study. SUBJECTS AND METHODS: Eighteen subjects 18-45years of age were randomly assigned (2:1 ratio) to receive apixaban or matchedplacebo. Subjects received a single 10 mg dose of apixaban or placebo on day 1,followed by 10 mg apixaban or placebo twice daily for 6 days (days 4-9). The PKand PD of apixaban were assessed by collecting plasma samples for 72 hoursfollowing the dose on day 1 and the morning dose on day 9, and measuringapixaban concentration and anti-Xa activity. Safety was assessed via physicalexaminations, vital sign measurements, electrocardiograms, and clinicallaboratory evaluations. RESULTS: PK analysis showed similar characteristics ofapixaban after single and multiple doses, including a median time to maximumconcentration of ~3 hours, mean elimination half-life of ~11 hours, and renalclearance of ~1.2 L/hour. The accumulation index was 1.7, consistent withtwice-daily dosing and the observed elimination half-life. Single-dose datapredict multiple-dose PK, therefore apixaban PK are time-independent. Therelationship between anti-Xa activity and plasma apixaban concentrationsappears to be linear. Apixaban was safe and well tolerated, with nobleeding-related adverse events reported. CONCLUSION: Apixaban was safe andwell tolerated in healthy Chinese subjects. Apixaban PK and PD were predictable andconsistent with findings from previous studies in Asian and non-Asian subjects.The administration of apixaban does not require any dose modification based onrace.
2: Cui, G Leng, H Wang, Ke;Wang, J Zhu, S Jia, J Chen, X Zhang, W Qin, LBai, WenpeiEffects of remifemin treatment on bone integrity and remodeling inrats with ovariectomy-induced osteoporosis.PloS one ):e82815
Department of Obstetrics and Gynecology, Peking UniversityFirst Hospital,Beijing, China. Department of Orthopaedics, Peking UniversityThird Hospital,Beijing, China. Department of Anatomy andEmbryology, Peking University HealthScience Center,Beijing, China. Statistics Office, Peking UniversityFirst Hospital,Beijing, China. Department of Stomatology, General Hospitalof Armed Police, Beijing, China.
This study aims to evaluate the effects ofRemifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausalosteoporosis. 120 female Sprague-Dawley rats were randomly assigned to fourgroups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy withestradiol valerate, or ovariectomy with Remifemin. Daily oral administrationsof the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgeryand lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at eachtimestep with assessment of bone mineral density, trabecular bone structure,and biomechanical parameters of the femur and lumbar vertebra. Bone turnovermarkers were evaluated 12 weeks after surgery. Both drugs prevented bonedensity loss in the distal end of the femur and preserved the trabecular bonestructure in both the lumbar vertebra and distal end of the femur followingovariectomy. Both drugs protected bone stiffness at the tested regions andreduced bone reabsorption in ovariectomized rats. The preventive effects ofRemifemin against bone-loss can rival those of estradiol valerate if treatmentduration is adequately extended. In conclusion, Remifemin may demonstrateequivalent effects to estradiol valerate in terms of preventing postmenopausalosteoporosis.
3: Wang, Q Wang, Rong- Zhang,J Zhou, YunDifferential diagnosis of pulmonary lesions by parametricimaging in (18)F-FDG PET/CT dynamic multi-bed scanning.Journal of B.U.ON. :official journal of the Balkan Union of Oncology 2013 Oct-Dec, 18(4):928-34
Department of Nuclear Medicine, Peking UniversityFirst Hospital,Xichengqu, West District, Beijing, P. R. of China.
PURPOSE: Benign and malignant pulmonarylesions are not easy to distinguish in a clinical setting. We investigated thefeasibility of using parametric imaging of the rate constant Ki to diagnose thenature of pulmonary lesions. METHODS: Dynamic multi-bed scanning followed by aroutine examination was performed on 21 patients with pulmonary lesions whowere divided into two groups with malignant or benign lesions based on biopsyand follow-up. The number of patients in the malignant and benign groups were10 with 15 lesions and 11 with 14 lesions, respectively. The left ventricularblood pool was used for an image-derived input function. The influx rateconstant Ki of the pulmonary lesions and parametric images was generated withthe Patlak plot method, and the inter-group differences for Ki, maximumstandardized uptake value (SUVmax), and the time-activity curves (TAC) offluorine-18-fludeoxyglucose ((18)F-FDG) were analyzed. At the same time, weinvestigated the correlation of Ki to SUVmax. RESULTS: The maximum diameters ofthe pulmonary lesions were not significantly different between the malignantand benign groups (p&0.05). Ki and SUVmax were significantly higher inmalignant lesions compared to benign lesions (p&0.05). Ki was highlycorrelated with SUVmax in pulmonary lesions (r=0.815, p&0.01). The malignantlesions showed gradually increasing TAC, and benign lesions exhibited graduallydecreasing curves. The parametric images of Ki were useful to distinguishmalignant lesions from normal tissue. CONCLUSION: Our results indicate that Kiparametric imaging in (18)F-FDG PET/computed tomography (CT) dynamic multi-bedscanning may be useful in the differential diagnosis of pulmonary lesions.
4: Chen, M Zheng, Bo; Wu, Z Peng,Hong-Yu; Wang, Xin-G Zhang, B Huo, YongEfficacy and safety of a novelnano-porous polymer-free sirolimus-eluting stent in pigs.Chinese medicaljournal ):4731-5
Heart Center of Peking University FirstHospital, Beijing 100034, China. Heart Center of Peking University FirstHospital, Beijing 100034, China. Email: .
BACKGROUND: Drug-eluting stents represent amajor advance in interventional cardiology. However, the current drug-elutingstents have significant limitations. One of the major problems is very latestent thrombosis, which is likely caused by inflammation and a hypersensitivityreaction related to a polymer on the stent. A polymer-free sirolimus-elutingstent with a unique nano-porous surface has been developed. This study aimed toevaluate this novel polymer-free sirolimus-eluting stent for its efficacy andsafety in a pig model. METHODS: Stents were directly coated with sirolimus (adrug concentration of 2.2 ug/mm(2) on the stent surface). The polymer-freesirolimus-eluting stents (PFSES) were compared to standard polymer-coatedsirolimus-eluting stents (PCSES) and bare-metal stents (BMS) in 18 pigs.RESULTS: At one month the degree of neointimal hyperplasia was similar betweenthe two sirolimus-eluting stent groups and was significantly less compared toBMS ((1.93 ± 0.51) mm(2), (1.57 ± 0.69) mm(2) vs. (4.45 ± 1.05) mm(2), P &0.05) At three months, PFSES maintained the low level of neointima ((2.41 ±0.99) mm(2) vs. (4.32 ± 1.16) mm(2), P & 0.05), whereas PCSES had developedsignificant neointimal proliferation similar to BMS. The inflammation level wassignificantly higher in PCSES when compared with BMS three monthspost-implantation (2.50 ± 0.55 vs. 0.83 ± 0.75, P & 0.05) whereas PFSESshowed a low level of inflammation comparable to PCSES (1.33 ± 0.52 vs. 2.50 ±0.55, P & 0.05). CONCLUSION: The PFSES is effective and safe, and appears tobe superior to standard PCSEs.
5: Yang, Zhi- Han, F Qin, JLiu, Xiao-yan[Diagnosis and treatment of epilepsy and narcolepsycomorbid].Zhonghua er ke za zhi. Chinese journal of pediatrics 2013/Sep,51(9):676-8
Department of Pediatrics, Peking UniversityFirst Hospital, Beijing 100034, China. Email: dr_.
OBJECTIVE: To analyze the clinicaldiagnosis and treatment process of narcolepsy and epilepsy co-existence, andthereby to improve awareness of such cases. METHOD: The clinical manifestationsof 2 cases were observed, and video-electroencephalogram (VEEG), multiple sleeplatency tests (MSLT) were performed. Hypocretin 1 level in cerebrospinal fluidwas examined in one case. RESULT: The onset of disease of case one was startedwith epilepsy with myoclonic seizure. After half a year, catalepsy induced byemotion especially laughing and excessive daytime sleepiness appeared. MSLT waspositive and hypocretin 1 level decreased. Narcolepsy-cataplexy was definitelydiagnosed in this case. Valproate was given and seizure was controlledcompletely, but the excessive daytime sleepiness was aggravated. Combination ofvalproate, methylphenidate and clomipramine treatment improved the symptoms ofnarcolepsy and the patient was still free of epileptic seizures. The onsetsymptoms of case 2 were catalepsy and excessive daytime sleepiness. MSLT waspositive. The treatment was ineffective because of bad compliance. After 2years, episodes of impairment of consciousness with automatism occurred. VEEGshowed slow waves and spikes in right temporal area. Complex partial seizurewas determined. Oxcarbazepine was used and then the patients became seizuresfree, but the symptoms of narcolepsy were still obvious. CONCLUSION:Comorbidity of narcolepsy and epilepsy is a rare phenomenon. Clinical symptoms,predisposing factor, VEEG and MSLT can help diagnosis and differentialdiagnosis. The antiepileptic drugs might aggravate drowsiness. Based on therapyof epilepsy by using antiepileptic drugs, low dosage of central nervous systemstimulants might improve the drowsiness and catalepsy symptoms of narcolepsy.
6: Zhong, Z Zhao, En-M Liu, Yu-He;Xiao, Shui-Fang[Fourth branchial abnormity and management experiences].Zhonghuaer bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngologyhead and neck surgery 2013/Jul, 48(7):592-5
Department of Otorhinolaryngology Head andWeek Surgery, Peking University First Hospital, Beijing 100034, China.
OBJECTIVE: To investigate the fourthbranchial abnormity and its managements. METHOD: Twelve cases of the fourthbranchial abnormity treated between January 2005 and April 2012 were reviewed.RESULTS: Dissection of the recurrent laryngeal nerve was done in all cases.Partial thyroidectomy was performed in 10 cases, and 2 cases of them receivedselective neck dissection including level II, III, IV and VI. The abnormity lesionswere found to pass posterior to the thyroid glands in the 10 cases and to passthrough the inferior constrictor muscle into the pyriform sinus in 7 cases ofthem. The internal opening in the pyriform sinus demonstrated by preoperativeexamination couldn’t be identified in the operation in one case. The abnormitytract terminated at the lateral surface of the esophagus in one case, passedinto the cervical esophagus in one case, and terminated at the lateral surfaceof the thyroid gland in one case, and formed a cyst lateral to the thyroidgland in one case. No abnormity tract was found to loop around the hypoglossalnerve and to descend into the mediastinum. The left recurrent laryngeal nervewas cut off in one patient, although end to end anastomosis was performedimmediately, the patient was still complicated with left vocal cord paralysispostoperatively. The median follow-up time of the cases was 24 months (8-88months). One case was lost of follow up. No recurrence was found in 10 cases.Recurrence was found in one case, and no recurrence in 10 cases. CONCLUSIONS:The presentation of congenital the fourth branchial fistula is variatedsignificantly. Most abnormity lesions had close relations to the thyroid glandand the recurrent laryngeal nerve, thus the recurrent laryngeal nerve need toprotect and partial thyroidectomy might be considered. In the recurrent caseswhen the abnormity couldn’t be identified clearly, selective neck dissectionincluding level II, III, IV and VI should be done long term follow up should becarried out in the cases that the internal opening couldn’t be found.
7: Shen, H Zhao, En-M Xiao,Shui-F Qin, Y Jing, Zhi-B Li, Tian-Cheng[Treatments of oropharyngealanterior wall cancer by transhyoid surgery radiotherapy].Zhonghua er bi yan houtou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and necksurgery 2013/Jul, 48(7):573-7
Department of Otorhinolaryngology Head andNeck Surgery, Peking University First Hospital, Beijing 100034, China.
OBJECTIVE: To evaluate the transhyoidresection of oropharyngeal anterior wall cancer and oncological outcomes of thesurgery combined with radiotherapy. METHODS: A total of 24 cases with carcinomalocated in the anterior wall of oropharynx was reviewed. The TNM stages were asfollows: T2 in 7 cases, T3 in 2 cases, T4 in 15 NO in 7 cases, N1 in 4cases, N2 in 12 cases and N3 in 1 case. Tumor resection was performed viatranshyoid approach, including 9 cases with partial glossectomy + partiallaryngectomy, 7 cases with partial glossectomy + total laryngectomy, 7 caseswith total glossectomy + partial laryngectomy and 1 case with partialglossectomy alone pectoralis major myocutaneous flaps were applied to repairsynchronously the defects of tongue and lateral pharyngeal wall in 16 cases andthe defect of cervical skin in 1 case. Radial forearm free flap and sternohyoidmyocutaneous flap were used to repair the defect of tongue and lateral andposterior pharyngeal wall in 1 case. Sternohyoid myocutaneous flap was appliedto reconstruct the tongue base in 2 cases. Bilateral and unilateral neckdissections were performed in 20 cases and 4 cases respectively. Five casesreceived preoperative radiotherapy and 16 cases received postoperative radiotherapy.RESULTS: All cases had negative surgical margin. Pathological examinationshowed neck lymph metastasis in 17 cases (70.8%). Three patients hadpostoperative pharyngocutaneous fistula. Two of them who underwent partialglossectomy + total laryngectomy and pectoralis major myocutaneous flapssynchronously reconstruction suffered from pharyngocutaneous fistula 4 daysafter operation. The fistula was closed by re-suturation following debridementand 2 weeks dressing change. The other one who underwent partial glossectomy +partial laryngectomy suffered from pharyngocutaneous fistula duringpostoperation radiotherapy and healed by the pectoralis major myocutaneousrepair. Tracheostomy tubes were removed within 1-6 months, with good voice andswallowing functions, in 16 of 17 cases who underwent partial laryngectomy.Another one failed to pull out tracheotomy tube because of dyspnea. Twenty onecases were followed up over 3 years and Kaplan-Meier survival analysis showedthe 3-year overall survival rate was 72.6%. CONCLUSIONS: The transhyoid tumorresection is an effective surgical approach for oropharyngeal anterior wallcancer. The defect following tumor resection is commonly need repairsynchronously with various flaps. Acceptable outcome could be received bysurgery combined with radiotherapy.
8: Xing, Y Wang, Jian- Pu,Cheng- Shang, Ke[Clinical evaluation of leukocyte differential count inperipheral blood by five-color flow cytometry].Zhonghua yi xue za zhi 2013/Aug,93(30):2392-6
Department of Clinical Laboratory Medicine,Peking University First Hospital, Beijing 100034, China.
OBJECTIVE: To explore the clinicalapplication values of five-color flow cytometry for leukocyte differentialcount in peripheral blood. METHODS: Leukocyte differentiation in 265 peripheralblood samples collected at Peking University First Hospital from September 2010to December 2010 was detected by standard microscopic cytology as a referencemethod. Meanwhile, Beckman-Coulter LH750 hematology analyzer and FC500 flowcytometer were performed. Then the correlations were analyzed betweenmicroscopic cytology, hematology analyzer and flow cytometry. Forty bloodsamples collected at Peking University First Hospital, Beijing Daopei Hospitaland General Hospital of Beijing Military Command from August 2010 to November2010 were analyzed by standard microscopic cytology, Beckman-Coulter LH750hematology analyzer and NAVIOS flow cytometer. Then the correlations betweenmicroscopy, hematology analyzer and flow cytometry were explored to analyze theclinical diagnostic efficiency of flow cytometry. RESULTS: Correlation ofleukocyte differential count between FC500 flow cytometer and standardmicroscopic cytology was significant (all P & 0.01) . And it was superior inthe detection of lymphocytes, neutrophils and eosinaphils (r = 0.955, 0.928,0.876). Moreover, the correlation of leukocyte differential count betweenNAVIOS flow cytometer via manual gate and standard microscopic cytology wassignificant (r & 0.700, all P & 0.01) except for basophils. And it wassuperior in the detection of neutrophils, lymphocytes and blasts (r = 0.950,0.915, 0.852). When 1% was set as the cut-off value of immature granulocytes onstandard microscopic cytology, the sensitivity and specificity of flowcytometry was 87% and 76% respectively. When 0.5% was set as the cut-off valueof blasts on standard microscopic cytology, the sensitivity and specificity offlow cytometry stood at 100% and 92% respectively. CONCLUSION: Five-color flowcytometry is well-correlated with standard microscopic cytology for leukocytedifferential count in peripheral blood with different flow cytometers, and thesensitivity of detecting blasts and immature granulocytes is very excellent.
9: Xie, F Su, M Qiu, W Zhang,M Guo, Z Su, B Liu, J Li, X Zhou, LiqunKaempferolpromotes apoptosis in human bladder cancer cells by inducing the tumorsuppressor, PTEN.International journal of molecular sciences ):21215-26
Department of Urology, Peking UniversityFirst Hospital & the Institute of Urology, Peking University, Beijing100034, China. .
Kaempferol (Kae), a natural flavonoid, iswidely distributed in fruits and vegetables. Previous studies have identifiedKae as a possible cancer preventive and therapeutic agent. We found Kae toexhibit potent antiproliferation and anti-migration effects in human bladdercancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependentmanner, as evidenced by increased cleavage of caspase-3. Furthermore, we foundKae-induced apoptosis in EJ cells to be associated with phosphatase and thetensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kaesignificantly increased PTEN and decreased Akt phosphorylation. Kae-inducedapoptosis was partially attenuated in PTEN-knockdown cells. Our findingsindicate that Kae could be an alternative medicine for bladder cancer, based ona PTEN activation mechanism.
10: Xu, R Han, QingF Zhu, TongYRen, Y Chen, JiangH Zhao, HuiP Chen, MengH Dong, J Wang,Y Hao, ChuanM Zhang, R Zhang, X Wang, M Tian, Na; Wang,HaiYanDiabetic patients could do as well as non-diabetic patients withoutinflammation on peritoneal dialysis.PloS one ):e80486
Renal Division, Department of Medicine,Peking University First Hospital, Institute of Nephrology, Peking University,Key Laboratory of Renal Disease, Ministry of Health, Key Laboratory of RenalDisease, Ministry of Education, Beijing, China.
BACKGROUND: Diabetic patients on peritonealdialysis (PD) have lower survival and are more likely complicated withinflammation than their non-diabetic counterparts. Here, we explored the interactioneffects between diabetes and inflammation on the survival of PD patients.METHODS: Overall, 2,264 incident patients were enrolled from a retrospectivecohort study in China. Patients were grouped according to the baseline levelsof high-sensitive C-reactive protein (hsCRP, ≤3 mg/L or &3 mg/L) or serum albumin (SA, ≥38 g/L or &38 g/L). Then,several multivariable adjusted stratified Cox regression models wereconstructed for these groups to explore the predicted role of diabetes onall-cause or cardiovascular death under inflammatory or non-inflammatoryconditions. RESULTS: Diabetics on PD were more likely to have inflammation thannon-diabetics on PD, and they presented with elevated hsCRP (52.7% vs. 47.3%, P= 0.03) or decreased SA (77.9% vs. 62.7%, P & 0.001) levels. Afterstratification by size of center and controlling for confounding factors,diabetes was found to predict all-cause death in patients with hsCRP &3 mg/Lor SA &38 g/L but not in patients with hsCRP ≤3 mg/L or SA ≥38 g/L. Similarly, the presence of diabetes was an indication ofcardiovascular death in patients with hsCRP &3 mg/L or SA &38 g/L.However, if further adjusted by baseline cardiovascular disease, the predictedrole of diabetes on death related to cardiovascular disease in patients with SA&38 g/L disappeared. CONCLUSION: Diabetic patients could do as well asnon-diabetic patients without inflammation on peritoneal dialysis. Activestrategies should be implemented to improve inflammation status in diabeticpatients on PD.
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