241 LEVELS OF SPO2 BETWEEN 85% AND 93% ARE ASSOCIATED WITH NORMOXEMIA IN NEWBORNS RECEIVING OXYGEN THERAPY (FIO2 & 0.21) IN THE NEONATAL INTENSIVE CARE UNIT. | Journal of Investigative MedicineSimultaneous determination of two alisols in Rhizoma Alismatis by HPLC-MS--《Shandong Science》2017年03期
Simultaneous determination of two alisols in Rhizoma Alismatis by HPLC-MS
CHI Yu-WANG Xiao-ZHANG LLIN Sha-JIANG Hai-ZHOU Hong-College of Pharmacy,Shandong University of Traditional Chinese MExperience Center of Shandong University of Traditional Chinese M
To improve the quality control of the Rhizoma Alismatis,a HPLC-MS method for determination of the contents of two alisols in Rhizoma Alismatis was established in this paper. Chromatographic conditions were as follows: Halo C_(18) column(2. 1 mm × 100 mm,2. 7 μm),the mobile phase was a mixture of 0. 1% formic acid solution-0. 1% formic acid in acetonitrile,gradient elution,the flow rate was 0. 3 m L·min-1,the column temperature was 30 ℃. The conditions of MS included: ESI ion source,detection method with positive ions,mode by MRM,drying temperature was 350 ℃,the flow rate of drying gas was 9 L·min-1,pressure of nebulizer was 241. 3 k Pa,and the voltage of capillary was 4 000 V. The content of alisol B 23-acetate and alisol A 24-acetate in the samples was 11. 459 5 μg · g~(-1)and 321. 823 9 μg · g~(-1),respectively. The method is accurate and reproducible to the determination of two alisols in Rhizoma Alismatis.
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O657.63;R284.1
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Analysis of ocular surface and meibomian glands in visual display terminal dry eye patients
XI LZHANG CZHAO Shao-Zthe Eye Hospital of Tianjin Medical University,Tianjin Medical University Eye Institute,School of Optometry and Ophthalmology,Tianjin Medical U
Objective To evaluate the role of meibomian gland dropout and expression of meibum in symptoms of young visual display terminal( VDT) dry eye patients. Methods Fifty clinically diagnosed VDT dry eye patients( 100 eyes) were enrolled between October 2014 and January 2015 in refractive and corneal outpatient of Tianjin Medical University Eye Hospital. All volunteers were divided into two groups,28 volunteers of short time VDT group( per day ≤ 4hours) and 22 volunteers of long time VDT group( per day
4 hours). All volunteers were further classified into two groups according to the ocular surface disease index( OSDI) score,30 volunteers of mild to moderate symptomatic( 13. 0 ≤OSDI ≤32. 5) group,20 volunteers of severe symptomatic( 32. 5
OSDI≤100. 0) group. Tear river height,tear film break-up time,meibomian gland dropout,corneal fluorescein staining and expression of meibum were visualized by meibography and slit lamp microscope. Results OSDI in long time VDT group and short time VDT group were 28. 15 ± 11. 28,22. 93 ± 9. 75,tear film break-up time were( 5. 84 ± 1. 95) s,( 4. 75 ± 1. 59) s,corneal fluorescein staining score were 3. 08 ± 1. 70,2. 21 ± 2. 02,meibomian gland dropout degree were 2. 50 ± 1. 11,1. 89 ± 0. 91,and meibum expression assessment score were 2. 11 ± 0. 80,1. 75 ± 0. 86( all P
0. 05). The tear river height in long time VDT group and short time VDT group were( 0. 19 ± 0. 04) mm and( 0. 20 ± 0. 04) mm( P = 0. 069). BUT in severe symptomatic group and mild to moderate symptomatic group were( 4. 68 ± 1. 77) s,( 5. 61 ±1. 81) s,corneal fluorescein staining score were 3. 50 ± 1. 50,2. 10 ± 2. 01,meibomian gland dropout degree were 2. 48 ± 1. 01,2. 05 ± 1. 03,and meibum expression assessment score were 2.23 ± 0. 62,1. 80 ± 0. 90( all P
0. 05),while the tear river height were( 0. 19 ± 0. 05) mm,( 0. 20 ± 0. 04) mm( P = 0. 428). Meibomian gland dropout degree was positively correlated with OSDI score( r = 0. 222,P = 0. 026) and corneal fluorescein staining score( r =0. 241,P = 0. 016). Meibum expression was positively correlated with OSDI score( r = 0. 205,P = 0. 041) and corneal fluorescein staining score( r = 0. 311,P = 0. 002). Conclusion There is no significant correlation between tear volume and degree of ocular surface symptoms in VDT dry eye patients. Meibomian gland dropout and increased difficulty of meibum expression might be important factors in causing dry eye discomfort.
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Ye Yuan1, Shu-Xi He 2 1Major in Ophthalmology, Medical College of University of South China, Hengyang 421001, Hunan Province, C2Ophthalmic and Optometric Center of Hunan Provincial People's Hospital, Changsha 410005, Hunan Province, C[J];International Eye S2012-05
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Xiao-Ping Ma;John D.Ng;Department of Ophthalmology,Zhong Shan Hospital Affiliated Fu Dan University,School of MOphthalmic Facial Plastic Surgery,Casey Eye Institute,Oregon Health and Sciences University P;[J];International Eye S2014-03
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