baroreceptor reflex是什么意思_百度知道
baroreceptor reflex是什么意思
提问者采纳
septə ˈˈb&#230.首先;r&#601。请采纳如果你认可我的回答;fleks
[美]&#716，~如果你认可我的回答;ptɚbæri&#716baroreceptor reflex
[英]ˌri，敬请及时采纳;flɛs&#603，记得好评和采纳, the researchers demonstrated that chronically hypertensive mice showed dramatically decreased baroreceptor reflex sensitivity and ace2 activity，请及时点击【采纳为满意回答】按钮~~手机提问的朋友在客户端右上角评价点【满意】即可; ˈr&#618，研究人员指出患有慢性高血压的老鼠所表现的压力感受反射敏感性和ace2活动的显著降低:ˌriˈrəks
压力感受拼射
[例句]First 。~你的采纳是我前进的动力~~O(∩_∩)O
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出门在外也不愁Gene transfer of angiotensin-converting enzyme 2 in the nucleus tra...
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):456-61. doi: 10.. Epub
2011 Jun 30.Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats.1, , , , , , .1Department of Physiology and Functional Genomics, College of Medicine and McKnight Brain Institute, University of Florida, Gainesville, FL, USA. mayamaz-ryk@umin.ac.jpAbstractThe renin-angiotensin system (RAS) in the nucleus tractus solitarius (NTS) is an important modulator of the baroreceptor heart rate reflex. This study tested the hypothesis that angiotensin-converting enzyme 2 (ACE2) expression is decreased in the NTS of spontaneously hypertensive rats (SHRs) and that its gene transfer in this nucleus would lead to beneficial effects on baroreflex function since this enzyme is key in the regulation of the vasoprotective axis of the RAS. ACE2 protein levels and its activity were significantly decreased in the NTS of SHRs compared to normotensive Wistar-Kyoto (WKY) control rats. Rats instrumented with radio-telemetry transducers received NTS microinjection of either Lenti-ACE2 (Lentiviral vector-mediated gene transfer of ACE2) or lenti-GFP (green fluorescent protein). The ACE2 gene transfer into the NTS resulted in long-term overexpression of ACE2. This was associated with a 60% increase in heart rate baroreflex sensitivity in the lenti-ACE2 injected SHRs compared with the lenti-GFP injected control SHRs (0.27 ± 0.02 ms/mmHg in lenti-GFP rats vs. 0.44 ± 0.07 ms/mmHg in lenti-ACE2 rats). These observations demonstrate that ACE2 gene transfer overcomes its intrinsic decrease in the NTS of SHRs and improves baroreceptor heart rate reflex.PMID:
[PubMed - indexed for MEDLINE] PMCID: PMC3375591 ACE2 expression in the NTS of WKY rats and SHRs. (A) ACE2 mRNA levels in the NTS: the caudal NTS were punched out bilaterally from four WKY and four SHR rats, and punches were subjected to RNA isolation protocol. Twenty-five nanograms of total RNA were utilized in real-time (RT) PCR as described in Methods. Primers and probe to 18S were used to normalize the data. Data are the mean ± SE from four rats. *p & 0.05 vs. WKY rats. (B) Representative Western blot of ACE2 protein band in the NTS: 20 μg of protein isolated from the NTS punches was subjected to SDS-PAGE and Western blotting as described in Methods. (C) Quantitation of the ACE2 protein band after normalization with α-tubulin. Data are the mean ± SE (n = 8). *p & 0.05 vs. WKY rats. (D) ACE2 enzyme activity was measured as described in Methods. Data are the mean ± SE (n = 8). *p & 0.05 vs. WKY rats. AFU: absolute fluorescence unit..J Renin Angiotensin Aldosterone Syst. ;12(4):456-461.Transduction of the NTS with lenti-ACE2. (A) Representative microphotograph of a lenti-GFP injected caudal NTS of SHR: GFP expression was restricted to the caudal NTS. The scale bar denotes 200μm. CC: central canal. (B) ACE2 activity following lenti-ACE2 treatment: the caudal NTS were punched out bilaterally from lenti-GFP injected and lenti-ACE2 injected SHRs. ACE2 activity was measured as described in Methods. Data are the mean ± SE (n = 4/group). *p & 0.05 vs. lenti-GFP.J Renin Angiotensin Aldosterone Syst. ;12(4):456-461.Effects of lenti-ACE2 administration into the NTS on baroreflex sensitivity. (A) Resting levels of MAP before baroreflex challenging test in lenti-GFP injected rats and lenti-ACE2 injected rats in both strains. (B) Representative traces of arterial pressure (AP) and heart rate (HR) in response to intravenous injection of phenylephrine (3μg) in lenti-GFP (left) and lenti-ACE2 (right) injected SHRs. Baroreflex function was examined by bolus intravenous injection of phenylephrine. (C) HR baroreflex sensitivity. HR baroreflex sensitivity was calculated by the ratio of change in pulse interval (ms) to change in mean arterial pressure (mmHg) produced by graded doses of intravenous phenylephrine (1 and 3μg in 0.05ml of normal saline). Data are the mean ± SE, n = 5–7 in each group. *p & 0.05 vs. lenti-GFP-treated SHRs.J Renin Angiotensin Aldosterone Syst. ;12(4):456-461.Publication TypesMeSH TermsSubstancesGrant SupportFull Text SourcesOther Literature SourcesResearch Materials
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