前两天下面不舒服有点痒，尿尿有点疼，自己用洁尔阴洗了2天，好转一点，后来发现阴道口长了好多点点，像鱼卵一样，好像里面也有，有一点点痒，昨天去医院做了个白带检查，上面写清洗度2，医生给我开了保妇康栓和甘霖洗剂，也没告诉我是什么问题。我想问问专家这是什么问题？昨天晚上睡觉前用甘霖洗剂洗和冲洗器洗了阴道，后和老公ML的时候小妹妹有点疼，早上起来就觉得尿尿很疼，用纸擦的时候上面有血丝，我不知道是尿尿的血丝
来自于：安徽|
提问时间： 14:17:47|
病情描述：
前两天下面不舒服有点痒，尿尿有点疼，自己用洁尔阴洗了2天，好转一点，后来发现口长了好多点点，像鱼卵一样，好像里面也有，有一点点痒，昨天去医院做了个检查，上面写清洗度2，医生给我开了保妇康栓和甘霖洗剂，也没告诉我是什么问题。我想问问专家这是什么问题？昨天晚上睡觉前用甘霖洗剂洗和冲洗器洗了阴道，后和老公ML的时候小妹妹有点疼，早上起来就觉得尿尿很疼，用纸擦的时候上面有血丝，我不知道是尿尿的血丝还是从阴道里出来的血丝，很，不知道自己到底怎么了，希望专家能帮我解释下。谢谢啊。。
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妇产科医生
妇产科医生
妇产科医生Is additional testing necessary in men with prostate-specific antigen levels of 1.0 ng/mL or less in a population-based screening setting? (ERSPC, ...
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):343-6.Is additional testing necessary in men with prostate-specific antigen levels of 1.0 ng/mL or less in a population-based screening setting? (ERSPC, section Rotterdam).1, , .1Department of Urology, Erasmus Medical Centre, Rotterdam, The Netherlands. m.roobol@erasmusmc.nlAbstractOBJECTIVES: Currently, several prostate cancer rescreening intervals are in use in different countries worldwide, varying from 1 to 4 years. Recently, it has been proposed to determine the rescreening interval relative to the initial prostate-specific antigen (PSA) level and possibly to extend the rescreening interval up to 5 years.METHODS: We evaluated the screening results of two subsequent screening visits (4-year interval) of 1703 men aged 55 to 65 years with an initial PSA level of 1.0 ng/mL or less within a randomized screening trial. We assessed the PSA values, numbers of men biopsied (biopsy indication: PSA level of 3.0 ng/mL or greater), and numbers of cancers detected at the second and third screening visits.RESULTS: A total of 1327 men (79.3%) attended the second screening visit. Of these men, 13 (0.98%) had a PSA level of 3.0 ng/mL or greater, and three cancers were detected (cancer detection rate 0.23%). At the third screening visit, 1017 men (76.8%) attended, 34 men (3.3%) had a PSA level of 3.0 ng/mL or greater, and five cancers were detected (cancer detection rate 0.49%). The 2344 subsequent PSA determinations in an 8-year period after the initial screening resulted in eight cancers detected, for an overall cancer detection rate of 0.47%. Through linkage of all men with the cancer registry, no additional cancers were found.CONCLUSIONS: A strategy of PSA screening every 8 years for men with a PSA level of 1.0 ng/mL or less will lead to a considerable decrease in the number of screening visits (with the associated costs and stress), with a minimal risk of missing aggressive cancer at a curable stage.PMID:
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{"words":"$head_words:结直肠肿瘤+$head_words:环氧化酶2+$head_words:Wnt\\/β\\-catenin信号通路+$head_words:血管内皮生长因子","themeword":"$head_words","params":"$title:COX\\-2\\/PGE2激活Wnt\\/β\\-catenin信号通路调控人肠癌细胞VEGF表达"}
&&&COX-2/PGE2激活Wnt/β-catenin信号通路调控人肠癌细胞VEGF表达
COX-2/PGE2激活Wnt/β-catenin信号通路调控人肠癌细胞VEGF表达
COX-2/PGE2 regulates VEGF expression by activating Wnt/β-catenin signal pathway in human colorectal cancer cells
目的 探讨环氧化酶2(COX- 2)/前列腺素E2(PGE2)是否通过Wnt/β-catenin信号通路调控人肠癌细胞血管内皮生长因子(VEGF)的表达.方法 将PGE2或COX-2选择性抑制剂NS-398作用LoVo细胞24 h,采用蛋白质印迹法检测COX-2和β-catenin蛋白表达；将PGE2和(或)β-catenin/tcf抑制剂FH-535作用LoVo细胞24 h,采用ELISA法检测VEGF表达.以常规培养的LoVo细胞为对照.结果 与对照组比较,PGE2能够上调LoVo细胞中COX-2蛋白表达,同时上调β-catenin在细胞总蛋白、细胞浆蛋白和核蛋白中的表达水平(分别是对照组的3.8倍、2.7倍和3.0倍,P均＜0.01)；COX-2抑制剂能够下调COX-2蛋白表达,同时下调β-catenin在细胞总蛋白、细胞浆蛋白和核蛋白中的表达水平(分别是对照组的0.3倍、0.3倍和0.2倍,P均＜0.01).与对照组比较,PGE2能够上调LoVo细胞VEGF表达水平(是对照组的1.6倍,P＜0.01)；β-catenin/tcf抑制剂能够下调VEGF表达(是对照组的0.68倍,P＜0.01)；将PGE2和β-catenin/tcf抑制剂同时作用LoVo细胞后VEGF表达水平与对照组相比差异无统计学意义(P＞0.05).结论 COX-2/PGE2通过上调β-catenin蛋白表达,从而激活Wnt/β-catenin信号通路,上调VEGF表达,这可能是COX-2/PGE2促进大肠癌血管新生的机制之一.
摘要： 目的 探讨环氧化酶2(COX- 2)/前列腺素E2(PGE2)是否通过Wnt/β-catenin信号通路调控人肠癌细胞血管内皮生长因子(VEGF)的表达.方法 将PGE2或COX-2选择性抑制剂NS-398作用LoVo细胞24 h,采用蛋白质印迹法检测COX-2和β-catenin蛋白表达；将PGE2和(或)β-catenin/tcf抑制剂FH-535作用L...&&
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